J Neurol Surg B Skull Base 2025; 86(S 01): S1-S576
DOI: 10.1055/s-0045-1803859
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Complications in the Endoscopic Endonasal Approach for Trigeminal Schwannomas: Systematic Review and Meta-analysis

Authors

  • Filipe V. Ribeiro

    1   Barão de Mauá, Faculty of Medicine, Ribeirao Preto, Brazil

  • Lucca Palavani

    2   Max Planck University Center, Indaiatuba, São Paulo, Brazil

  • Marcelo P. Porto Sousa

    3   Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

  • Filipi F. Andreão

    3   Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

  • Maria Antônia Pereira

    4   State University of Piauí, Faculty of Medicine, Teresina, Piauí, Brazil

  • Ary Neto

    5   Faculty of Medicine Multivix, Cachoeiro de Itapemirim—ES, Brazil

  • Christian Fukunaga

    6   Faculty of Medicine, FMABC University Center, São Paulo, Brazil

  • Luis Paleare

    7   School of Medicine, Pontifical Catholic University of Paraná, Curitiba, PR, Brazil

  • Márcio Ferreira

    8   Department of Neurosurgery, Lenox Hill Hospital/Northwell Health, New York, New York, United States

  • Raphael Bertani

    9   Department of Neurosurgery, University of São Paulo, São Paulo, Brazil

  • Allan Polverini

    10   Neurosurgical Oncology Division, Department of Neurosurgery, Barretos Cancer Hospital, Barretos, São Paulo, Brazil

  • Naresh Patel

    11   Department of Neurosurgery, Mayo Clinic Hospital, Arizona, United States

  • Herika Negri

    11   Department of Neurosurgery, Mayo Clinic Hospital, Arizona, United States
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    Introduction: Trigeminal schwannomas (TSs) are the second most common type of intracranial schwannoma. Surgical approaches are chosen depending on the type of tumor extension. The middle fossa extradural approach, infratemporal extradural approach, transmaxillary approach, transmandibular approach, and transcervical approach have been used. However, these approaches are associated with a variety of complications including other cranial nerve dysfunction. Recently, with the wide application of endoscopic technology, the endoscopic endonasal approach (EEA) seems to be an alternative skull base surgical approach for skull base pathology.

    Objective: The objective of the present study is to evaluate the safety endoscopic endonasal approach for trigeminal schwannomas.

    Methods: We searched Medline, Embase, and Web of Science databases following PRISMA guidelines. We used single proportion analysis with 95% confidence intervals under a random-effects model, I2 to assess heterogeneity, and Baujat and sensitivity analysis to address high heterogeneity. Eligible studies included those with ≥3 patients treated with an endoscopic endonasal approach for trigeminal schwannomas.

    Results: From 2,550 initially identified studies, 8 were selected, involving 187 patients, with a median follow-up of 36 months. The combined analysis showed a 5% (CI: 0–13%).

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    Conclusion: Based on these findings, our meta-analysis identified that the endonasal endoscopic approach for the treatment of trigeminal schwannomas presents a low rate of complications.


     

    No conflict of interest has been declared by the author(s).

    Publication History

    Article published online:
    07 February 2025

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