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DOI: 10.1055/s-0045-1806865
Feasibility and Safety of the REVERT Technique for Single-Access Endovascular Treatment of Peripheral Artery Disease
Abstract
Objective
Peripheral artery disease (PAD) is associated with increased mortality, limb loss, and disability, impacting over 230 million individuals globally. The REVERT technique, designed for single-access management of ipsilateral lower extremity PAD, may reduce complications related to multiple punctures. This study aims to evaluate the efficacy and safety of the REVERT technique in endovascular interventions.
Methods
This retrospective study reviewed 12 patients treated with the REVERT technique at our institution from January 2019 to October 2022. Patient demographics (age, gender, Rutherford classification) and procedural data (sheath sizes, puncture methods, hemostasis techniques) were collected. Complications were assessed based on the Society of Interventional Radiology standards.
Results
The mean age of the cohort was 72 years, with 75% male patients, and 58.3% presented with critical ischemia (Rutherford ≥4). No acute limb ischemia cases were observed, and the REVERT technique was successfully performed in all cases without major complications. One case of sheath kinking was resolved by replacing it with a kink-resistant sheath.
Conclusion
The REVERT technique appears to be a safe and effective method for single-stage endovascular treatment of ipsilateral or bilateral PAD, with minimal complications. Larger-scale studies are recommended to further validate these findings and optimize clinical applications.
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Introduction
Atherosclerotic cardiovascular diseases, including peripheral artery diseases (PAD), affect over 230 million individuals worldwide, causing premature deaths, limb loss, and significant health care costs.[1] [2] Endovascular interventions have become the preferred treatment for PAD due to lower procedural risks compared with surgery.[3] The transfemoral approach, incorporating antegrade or retrograde catheterizations, is commonly used for arterial access, especially in complex cases requiring multiple strategies.[4]
Arterial punctures, while essential, carry risks such as dissections, pseudoaneurysm formation, and embolization, which increase with the number of puncture sites.[5] [6] [7] The “REVERT” technique offers a single-access approach to address ipsilateral PAD, potentially reducing these risks. However, concerns about femoral artery stress and operator challenges with ipsilateral superficial femoral artery (SFA) catheterization remain.[4]
This study retrospectively evaluates the safety and efficacy of the REVERT technique in patients treated at our institution over the past 3 years.
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Materials and Methods
Ethical Considerations
This retrospective study protocol adhered to the principles outlined in the Helsinki Declaration and received approval from the institutional review board under reference number 2022000604–1. Individual informed consent was routinely obtained from all patients for their procedures, but additional consent specific to the study was not required due to the retrospective nature of the research.
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Patient Population
Between January 2019 and October 2022, a total of 1,559 lower extremity angiographies were performed at our center for the treatment of PAD. Various arterial access sites, including femoral, axillary, brachial, popliteal, and below-the-knee (BTK) arteries, were used in these PAD interventions, depending on specific clinical scenarios. During this period, 12 patients treated with the REVERT technique were included in the study.
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Collection of Patient Data
We evaluated various patient demographic and clinical parameters, including age, gender, presence of acute limb ischemia (ALI), Rutherford classification, iliac artery calcification and tortuosity, history of prior lower extremity interventions, and use of antiplatelet or anticoagulant medications. Additionally, we examined the hemoglobin levels, international normalized ratio (INR), and platelet (PLT) counts from patient records.
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Collection of Procedural Data
We also collected and evaluated data on preferred sheath sizes, puncture technique (manual palpation or ultrasound [US] guidance), use of vascular closure devices or manual compression for achieving hemostasis, the side on which the procedures were performed, and the treated vessels.
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Complication Evaluation
Subsequently, we assessed primary and secondary complications. All procedures were performed by experienced operators, with the use of US for common femoral artery (CFA) punctures determined by the operator's preference. The significance of complications associated with the techniques used was evaluated using the adverse event classification system of the Society of Interventional Radiology.[8]
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Technique
Femoral puncture sites were evaluated by senior nurse practitioners or radiology residents according to institutional protocols. Patients were positioned supine, and femoral artery access was achieved using an 18-gauge hollow needle. For retrograde punctures, the arterial pulse guided site selection, with the needle inserted at a 45-degree angle. Anatomical landmarks or fluoroscopy were used when necessary to locate the femoral head.
When US guidance was applied, a 7.5-Hz linear probe (Sonosite M-Turbo, Bothell, WA, United States) was used, favoring plaque-free segments of the CFA for access. The REVERT technique employed a 0.035-inch stiff glidewire (Terumo, Japan), 5-Fr/6-Fr sheaths (Terumo or Cook, United States), and diagnostic catheters (e.g., Simmons 1/5 or C2 from Boston Scientific).
After diagnostic angiography, a diagnostic catheter formed a Waltman loop and was advanced into the terminal aorta. The wire and catheter were then pulled into the ipsilateral iliac artery and advanced into the SFA. The wire was left in the distal SFA, while the sheath and catheter were removed. Finally, the sheath was reversed to enable antegrade catheterization of the SFA (see [Fig. 1]).


Following the completion of the procedures, hemostasis was achieved through either manual compression or the use of a vascular closure device. It should be noted that, within our institution, the decision to utilize US guidance for arterial access or to select a specific vascular closure device for achieving hemostasis was at the discretion of the experienced interventional radiologist.
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Results
This study included 12 patients (mean age: 72 years; 75% male) who underwent the REVERT catheterization technique. Critical ischemia (Rutherford ≥4) was observed in 58.3% of patients, while moderate or severe iliac artery calcification and severe tortuosity were noted in 8.3 and 16.7% patients, respectively. One patient had a previously placed iliac stent. Laboratory values showed a mean hemoglobin of 12.3 g/dL, INR of 1.10, and PLT count of 265,580/mm3. Most patients (91.7%) were on single antiplatelet or anticoagulant therapy, and one (8.3%) was on dual therapy ([Table 1]).
Procedural data revealed that 58.3% of cases used a 5-Fr short sheath, while 33.3% and 8.3% of cases used a 6-Fr short sheath and a 6-Fr long sheath respectively. Puncture techniques involved manual palpation in 58.3% and US guidance in 41.7%. Hemostasis was achieved through manual compression in 91.7% of cases and a vascular closure device in 8.3%. Right-sided diagnosis and treatment were performed in 91.7% of cases, while bilateral treatment was performed in 8.3% ([Table 2]).
Target lesions included femoropopliteal and BTK (FP + BTK) lesions in 33.3%, BTK lesions in 25%, FP lesions in 25%, aortoiliac, femoropopliteal, and below-the-knee (AI + FP + BTK) lesions in 8.3%, and bilateral BTK lesions in another 8.3% ([Table 3]).
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Discussion
This study aimed to describe the application of the REVERT technique and demonstrate its safety and feasibility when performed by skilled operators. While retrograde femoral artery puncture is the traditional method for lower extremity angiography, and the antegrade approach allows more direct access for ipsilateral treatments, the REVERT technique offers a single-access solution for treating ipsilateral and bilateral lesions. However, it demands high technical expertise compared with standard approaches.
The REVERT technique has shown comparable efficacy and safety to established methods, with no significant complications reported in our study, consistent with previous findings.[4] [9] [10] A single case of sheath kinking was resolved by using a kink-resistant sheath, emphasizing the need for careful equipment selection, particularly in anatomically challenging cases. Operators should remain vigilant for such issues. A representative case is presented in [Fig. 2].


The REVERT technique offers a key advantage by reducing the need for multiple punctures, thereby minimizing entry site complications such as pseudoaneurysms and hematomas. This is particularly beneficial for high-risk populations, including those with coagulopathies or advanced atherosclerosis. Procedure success and complication rates are closely tied to the operator's skill and experience. In this study, all procedures were performed by experienced practitioners.
The study is limited by its small sample size, single-center design, and retrospective nature, as well as its dependence on operator expertise. Larger, multicenter prospective studies are required to validate these findings.
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Conclusion
The REVERT technique demonstrates potential as a safe and effective method for single-stage endovascular treatment of bilateral or ipsilateral PAD. In this series, the technique was successfully applied without significant complications, aligning with findings from existing literature.
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Conflict of Interest
None declared.
Ethical Approval
This retrospective study protocol adhered to the principles outlined in the Declaration of Helsinki and received approval from the institutional review board under reference number 2022000604–1.
Informed Consent
Individual informed consent was routinely obtained from all patients for their procedures, but additional consent specific to the study was not required due to the retrospective nature of the research.
Availability of Data and Materials
The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request.
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References
- 1 Ray KK, Ference BA, Séverin T. et al. World Heart Federation Cholesterol Roadmap 2022. Glob Heart 2022; 17 (01) 75
- 2 Gerhard-Herman MD, Gornik HL, Barrett C. et al. 2016 AHA/ACC Guideline on the management of patients with lower extremity peripheral artery disease: executive summary—a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 2017; 135 (12) e686-e725
- 3 Thukkani AK, Kinlay S. Endovascular intervention for peripheral artery disease. Circ Res 2015; 116 (09) 1599-1613
- 4 Kadoya Y, Zen K, Kato T. et al. Feasibility and safety of reverse catheterization technique of the superficial femoral artery in single-stage endovascular treatment of bilateral infrainguinal diseases. Vasc Endovascular Surg 2019; 53 (03) 206-211
- 5 Rajebi H, Rajebi MR. Optimizing common femoral artery access. Tech Vasc Interv Radiol 2015; 18 (02) 76-81
- 6 Irani F, Kumar S, Colyer Jr WR. Common femoral artery access techniques: a review. J Cardiovasc Med (Hagerstown) 2009; 10 (07) 517-522
- 7 Kinnaird TD, Stabile E, Mintz GS. et al. Incidence, predictors, and prognostic implications of bleeding and blood transfusion following percutaneous coronary interventions. Am J Cardiol 2003; 92 (08) 930-935
- 8 Khalilzadeh O, Baerlocher MO, Shyn PB. et al. Proposal of a new adverse event classification by the Society of Interventional Radiology Standards of Practice Committee. J Vasc Interv Radiol 2017; 28 (10) 1432-1437.e3
- 9 Hartnell G. An improved reversal technique from retrograde to antegrade femoral artery cannulation. Cardiovasc Intervent Radiol 1998; 21 (06) 512-513
- 10 Miralles M, Candela E, Blanes E, Ribé L. Reverse retrograde approach: an alternative method for ipsilateral access to the superficial femoral artery. EJVES Short Rep 2016; 30: 7-9
Address for correspondence
Publication History
Article published online:
26 March 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Ray KK, Ference BA, Séverin T. et al. World Heart Federation Cholesterol Roadmap 2022. Glob Heart 2022; 17 (01) 75
- 2 Gerhard-Herman MD, Gornik HL, Barrett C. et al. 2016 AHA/ACC Guideline on the management of patients with lower extremity peripheral artery disease: executive summary—a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 2017; 135 (12) e686-e725
- 3 Thukkani AK, Kinlay S. Endovascular intervention for peripheral artery disease. Circ Res 2015; 116 (09) 1599-1613
- 4 Kadoya Y, Zen K, Kato T. et al. Feasibility and safety of reverse catheterization technique of the superficial femoral artery in single-stage endovascular treatment of bilateral infrainguinal diseases. Vasc Endovascular Surg 2019; 53 (03) 206-211
- 5 Rajebi H, Rajebi MR. Optimizing common femoral artery access. Tech Vasc Interv Radiol 2015; 18 (02) 76-81
- 6 Irani F, Kumar S, Colyer Jr WR. Common femoral artery access techniques: a review. J Cardiovasc Med (Hagerstown) 2009; 10 (07) 517-522
- 7 Kinnaird TD, Stabile E, Mintz GS. et al. Incidence, predictors, and prognostic implications of bleeding and blood transfusion following percutaneous coronary interventions. Am J Cardiol 2003; 92 (08) 930-935
- 8 Khalilzadeh O, Baerlocher MO, Shyn PB. et al. Proposal of a new adverse event classification by the Society of Interventional Radiology Standards of Practice Committee. J Vasc Interv Radiol 2017; 28 (10) 1432-1437.e3
- 9 Hartnell G. An improved reversal technique from retrograde to antegrade femoral artery cannulation. Cardiovasc Intervent Radiol 1998; 21 (06) 512-513
- 10 Miralles M, Candela E, Blanes E, Ribé L. Reverse retrograde approach: an alternative method for ipsilateral access to the superficial femoral artery. EJVES Short Rep 2016; 30: 7-9



