Hereditary predisposition syndrome to breast and ovarian cancer: clinical profile of potential susceptibility in a public hospital in the eastern Amazon

Keywords

breast cancer - syndrome of hereditary predisposition - mutations

Introduction: Breast cancer is considered an important health problem public health, especially among developing countries, with mutations in brca1 and brca2 are responsible for most cancers attributed to single mutations and about 3% of all breast cancers, configuring the syndrome of hereditary predisposition to breast cancer and ovary (HBOC).

Objective: To evaluate the number of individuals who complete criteria for hereditary breast cancer predisposition syndrome and ovary among patients with breast cancer in a reference center in Belém – Brazil.

Methodology: An epidemiological study was carried out, observational, descriptive cross-sectional design of individuals who completed clinical criteria for HBOC, based on the national comprehensive cancer network (NCCN 2023) guideline among breast cancer patients in treatment. The research was carried out at the chemotherapy outpatient clinic of the João de Barros Barreto University Hospital – HUJBB, in the period of January 2023 to January 2024.

Results: Data were collected from 200 patients, of which 199 were female and 1 male. Another variable analyzed was age, with the majority (38 patients) in the age group between 51 and 55 years old, and 36.5% were under 50 years old. Regarding color, the majority of patients were brown (totaling 188 individuals). Regarding the education level observed, the vast majority had completed secondary education (80 people), followed by complete primary education (32 people). In the context of the molecular type, luminal b stood out with 34.5% of the total population and the least found was the her2 subtype, with 16 patients. In the context of histological type, 51.5% was represented by the non-special type. Regarding staging, 55% were stage i and ii and 6.5% were metastatic. And finally, regarding HBOC, 48 patients met clinical criteria, representing 24% of the population studied and deserve specialized oncogenetic evaluation.

Conclusion: The result made it possible to provide valuable data for monitoring of these patients and directing the attention of local health professionals for this group of individuals in order to stimulate actions that strengthen the prevention, early diagnosis and adequate genetic counseling.

Corresponding author: Amanda de Araújo Dias (e-mail: [e-mail]).

 

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No conflict of interest has been declared by the author(s).

Publication History

Article published online:
06 May 2025