Z Gastroenterol 2025; 63(08): e575
DOI: 10.1055/s-0045-1811018
Abstracts | DGVS/DGAV
Kurzvorträge
Endokrine Chirurgie Freitag, 19. September 2025, 10:55 – 12:07, Seminarraum 6 + 7

Initial experience with dual-time-point 18F-Flurpiridaz PET/CT for localization of parathyroid adenomas in primary hyperparathyroidism

Authors

  • T Derlin

    1   Medizinische Hochschule Hannover, Klinik für Nuklearmedizin, Hannover, Deutschland

  • D Kleine-Döpke

    2   Medizinische Hochschule Hannover, Klinik für Allgemein-, Viszeral- & Transplantationschirurgie, Hannover, Deutschland

  • L Neubert

    3   Medizinische Hochschule Hannover, Institut für Pathologie, Hannover, Deutschland

  • T L Ross

    1   Medizinische Hochschule Hannover, Klinik für Nuklearmedizin, Hannover, Deutschland

  • B P Ringe

    2   Medizinische Hochschule Hannover, Klinik für Allgemein-, Viszeral- & Transplantationschirurgie, Hannover, Deutschland

  • M Schmelzle

    2   Medizinische Hochschule Hannover, Klinik für Allgemein-, Viszeral- & Transplantationschirurgie, Hannover, Deutschland

  • F M Bengel

    1   Medizinische Hochschule Hannover, Klinik für Nuklearmedizin, Hannover, Deutschland
Further Information
Also available at
 
 

    Aim: To evaluate the feasibility of 18F-Flurpiridaz positron emission tomography/computed tomography (PET/CT) for localization of parathyroid adenomas in patients with primary hyperparathyroidism (pHPT).

    Methods: Data of 11 patients with pHPT undergoing dual-time point 18F-Flurpiridaz PET/CT for localization of hyperfunctioning parathyroid glands were retrospectively analyzed. PET/CT findings were compared to results of other imaging tests, laboratory parameters, and intraoperative findings and final histology, serving as the reference standard.

    Results: 18F-Flurpiridaz PET/CT identified parathyroid adenomas in 10/11 (91%) patients. Parathyroid adenomas were exclusively visualized in early PET images (P<0.0001). Uptake in adenomas declined over time (SUVmax, -65%±17%; P=0.002), as did uptake in background thyroid tissue (-56%±16%; P=0.002).

    Conclusion: 18F-Flurpiridaz PET early after tracer administration has high detection efficacy in pHPT. This work provides a rationale for larger prospective studies evaluating its potential for localization of hyperfunctioning parathyroid glands in comparison to other imaging tests.


     

    Publication History

    Article published online:
    04 September 2025

    © 2025. Thieme. All rights reserved.

    Georg Thieme Verlag KG
    Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany