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Semin intervent Radiol
DOI: 10.1055/s-0045-1812014
Review Article

Prevention of the Postthrombotic Syndrome: Where Do We Stand?

Authors

  • Suresh Vedantham

    1   Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri

Funding None.
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Abstract

The postthrombotic syndrome (PTS) is a common complication of lower extremity deep vein thrombosis (DVT) that impairs patients' health-related quality of life despite the use of standard therapy. Prevention of PTS is an important goal of quality DVT care, and includes prevention of recurrent DVT with anticoagulation, use of compression therapy, mitigation of functional contributors to limb edema, use of endovascular therapy to prevent venous obstruction and valvular reflux, and reduction of inflammation within the involved veins and limb. This study reviews best practices in clinical PTS prevention, clinical trial evidence on endovascular therapy outcomes, and mechanistic observations about PTS with the goal of preparing the interventional radiology physician to deliver outstanding patient care and to lead local and national multi-specialty initiatives that are aimed at PTS prevention.

Keywords

deep vein thrombosis - postthrombotic syndrome - thrombolysis - thrombectomy - pharmaco-mechanical - interventional radiology


Publication History

Article published online:
26 September 2025

© 2025. Thieme. All rights reserved.

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