Ultraschall Med 2025; 46(S 01): S16
DOI: 10.1055/s-0045-1812210
Abstracts
Mündliche Beiträge

Early Experiences with Multispectral Optical Tomography in Breast Lesion Imaging: A Comparative Study with Ultrasound, MRI, and Breast-CT

Authors

  • S Hosseinzadeh

    1   USZ, Radiologie, Zürich, Schweiz

  • A Martin

    1   USZ, Radiologie, Zürich, Schweiz

  • T Frauenfelder

    1   USZ, Radiologie, Zürich, Schweiz

  • D Razansky

    2   ETH Zurich, Department of Information Technology and Electrical Engineering, Zurich, Schweiz

  • F A Huber

    1   USZ, Radiologie, Zürich, Schweiz

  • C M Paverd

    1   USZ, Radiologie, Zürich, Schweiz
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    Background Multispectral Optical Tomography (MSOT) is a novel technique combining spectral optical and ultrasound (US)-based imaging for enhanced tissue characterization on a molecular level. Its potential in breast imaging has gained increasing interest due to its high sensitivity, non-invasive nature, and ability to provide tissue-specific information. However, there is limited data regarding its comparative effectiveness to established imaging modalities like US, magnetic resonance imaging (MRI), and computed tomography (CT) for breast lesions. This study aims to present our initial experiences with MSOT and its comparative performance in characterizing breast lesions.

    Methods We conducted a prospective study with over 50 patients presenting with follow-up scans or suspicious breast lesions, who underwent US, MRI, and/or CT imaging as part of their diagnostic workup. Additionally, MSOT images were acquired in a standardized way using a commercial system (iThera Acuity), with a focus on providing multispectral data to assess lesion characteristics such as blood volume, oxygen saturation, and tissue structure. The lesions were categorized based on their imaging features across all modalities. Lesion related profiles of MSOT were compared to conventional findings of malignancy in US, MRI, and CT, with histopathological results serving as the reference standard.

    Results MSOT proved particularly effective in visualizing tumor vascularity and quantification of oxygenation. Compared to standalone US, MSOT improved contrast in low-echogenicity lesions. Similarities in lesion vascularizaition were seen compared to MRI. CT had limited specificity in characterizing small lesions, were added value was also seen with MSOT.

    Conclusion First experiences with MSOT show a promising tool in breast imaging, providing high-resolution, functional imaging of breast lesions, with ability to visualize vascular characteristics and tissue-specific contrast. Large cohort studies are needed to validate these findings.


     

    Publication History

    Article published online:
    16 October 2025

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