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Fortschr Neurol Psychiatr 2000; 68(1): 25-36
DOI: 10.1055/s-2000-11790
ORIGINALARBEIT
Georg Thieme Verlag Stuttgart ·New York

30 Jahre MSA-Konzept:Ein Rück- und Überblick überdie Multisystematrophie

30 Years of MSA-Concept: Review and Survey of Multiple System Atrophy:S. Probst-Cousin, C. Kayser, D. Heuss, B. Neundörfer
  • Neurologische Klinik und Poliklinik der Friedrich-Alexander-Universität Erlangen-Nürnberg (Direktor: Prof. Dr. med.B. Neundörfer)
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Publication History

Publication Date:
05 November 2004 (online)

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Zusammenfassung:

Die Multisystematrophie (MSA) ist eine klinisch-neuropathologisch definierte neurodegenerative Erkrankung unklarer Ätiologie und Pathogenese. Die zuvor benutzten, historisch entstandenen Begriffe olivo-ponto-zerebelläre Atrophie, striato-nigrale Degeneration und Shy-Drager-Syndrom, die schon immer durch eine klinisch-morphologische Überlappung gekennzeichnet waren, sollten den klinischen Sprachgebrauch verlassen und neurodegenerative Erkrankungen mit einem komplexen morphologischen Läsionsmuster, die nicht der Definition der MSA entsprechen, sollten unter die Multisystemdegenerationen eingereiht werden.

Multiple system atrophy represents an enigmatic, clinico-pathologically defined neurodegenerative disease. According to findings of the last three decades, the historically derived, previously used terms olivopontocerebellar atrophy, striatonigral degeneration, and Shy-Drager-syndrome should be avoided in clinical use because of both the clinical and morphological overlap between these syndromes. Complex neurodegenerative syndromes other than multiple system atrophy according to recently developed criteria, should rather be referred to as multiple system degenerations.

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Dr. Stefan Probst-Cousin

Zentrum für Neuromuskuläre Erkrankungen

Neurologische Klinik und Poliklinik

der Friedrich-Alexander-Universität Erlangen-Nürnberg

Schwabachanlage 6

91054 Erlangen

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