Molekulare Radiologie.
Teil II: Molekulare Bildgebung

Zusammenfassung.

Es werden die wichtigsten Strategien zur Molekularen Bildgebung vorgestellt. Mittels moderner bildgebender Verfahren, d. h. mit SPECT, PET, MRT und hochentwickelten optischen Methoden, können die Vorgänge auf molekularer Ebene in vitro und in vivo abgebildet werden. Die Möglichkeit die Expression von Genen, therapeutischer DNA und von klassischen Pharmaka in vivo abzubilden, eröffnet dabei völlig neue Ansätze für die Erforschung, Diagnostik und Therapie von Erkrankungen. Der aktuelle Stand dieser Entwicklung wird beschrieben sowie potenzielle Anwendungsbereiche und Entwicklungsmöglichkeiten umrissen.

Molecular Radiology. Part ll: Molecular Imaging.

The most important strategies for molecular imaging are presented. Processes can now be imaged in vitro and in vivo at the molecular level with the help of modern procedures such as SPECT, PET, MRI, and highly developed optical methods. The ability to view the expression of genes, the pharmacokinetics of gene therapy vectors, of therapeutic DNA, and of classical pharmacons in vivo opens up completely new perspectives for the research on, diagnosis of, and therapy for diseases. The current status of these developments are described, potential fields of use and possibilities for further development are outlined

Schlüsselwörter:

Molekulare Bildgebung - Molekulare Bildgebung - Reportergen - Genexpression - MRT - PET

Key words:

Molecular imaging - reporter gene - gene expression - MRI - PET

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