Messung der Hautdicke mittels Hochfrequenzultraschall zur Objektivierung einer Hormonersatztherapie in der Perimenopause

Zusammenfassung

Studienziel: Die Studie hatte zum Ziel, die Hautdickenveränderungen, beeinflusst durch drei verschiedene Hormonersatztherapien (HRT), zu vergleichen. Methode: Die Hautdicke wurde mittels einer Hochfrequenz-Ultraschall-Technik bei perimenopausalen Frauen mit erniedrigtem Östradiol (< 45 pg/ml) an der Innenseite des linken Oberarmes bestimmt. Die Patientinnen wurden in Gruppen zusammengefasst: Gruppe 1 (n = 6) erhielt nur Östradiol transdermal; Gruppe 2 (n = 7) Östradiol transdermal und Progesteron vaginal; Gruppe 3 (n = 8) Östradiol oral und Progesteron vaginal; Gruppe 4 (n = 3) bildete die Kontrollgruppe ohne Therapie. Ergebnisse: Der Medianwert der Hautdicke von allen HRT-Gruppen zeigte eine hoch signifikante Zunahme von 0,15 mm nach sechs Monaten (0,91 mm vor Therapie versus 1,06 mm nach sechs Monaten HRT). Im Gegensatz zeigte sich bei der Kontrollgruppe kein signifikanter Unterschied. Schlussfolgerung: Die Studie zeigt, dass eine HRT zu einer Hautdickenzunahme führt, die mittels hochauflösendem Ultraschall gemessen werden kann.

Measurement of Skin Thickness by High-frequency Ultrasound to Objectify the Effects of Hormone Replacement Therapy in the Perimenopause

Aim: The aim of this study was to show the influence of three different hormone replacement therapy regimes (HRT) by comparing the changes in skin thickness. Method: Skin thickness was measured using a high-frequency ultrasound system on the inner side of the left upper arm of perimenopausal women with a low oestradiol level (< 45 pg/ml). The patients were allocated to different groups: Group1 (n = 6) received oestradiol merely transdermally; Group 2 (n = 7) was given transdermal oestradiol as well as progesterone vaginally; Group 3 (n = 8) took oral oestradiol and vaginal progesterone; Group 4 (n = 3) served as the control group without therapy. Results: The median value of skin thickness in all HRT-groups increased highly significantly (0.15 mm) after six months (0.91 mm before therapy versus 1.06 mm after six months of HRT), but there was no significant change in the control group. Conclusions: The study shows that HRT leads to an increase of skin thickness which can be demonstrated by a high-frequency ultrasound.

Schlüsselwörter:

Hautalterung - Hautdicke - Hormonersatztherapie - Hochfrequenzultraschall

Key words:

Skin ageing - Skin thickness - Hormone replacement therapy - High-frequency ultrasound

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