Signet-ring Cell Carcinoma of unknown primary Location. Metastatic to lower back Musculature - Remission following FU/FA Chemotherapy

Abstract

The detection of gastrointestinal signet-ring cell carcinoma by endoscopy can be a diagnostic challenge. The main clinical features include atypical metastasis and a poor prognosis.

We present a case of a metastasizing signet-ring cell carcinoma with unknown primary location arising in 71-year-old female. Following 6 cycles of a routine intravenous FU/FA chemotherapy, an almost complete remission could be observed. After 2 years of follow up, metastatic recurrence was detected to the lower back musculature.

This case report emphasizes the difficulties in diagnosing signet-ring cell carcinoma by endoscopy and demonstrates an unusual clinical course.

Zusammenfassung

Siegelringzellkarzinome des Gastrointestinaltraktes können eine diagnostische Herausforderung an den Endoskopiker darstellen. Sie sind oftmals durch atypische Metastasierung und eine schlechte Prognose gekennzeichnet.

In diesem Fallbericht wird ein bei einer 71-jährigen Patientin aufgetretenes Siegelringzellkarzinom mit unklarem Primarius vorgestellt. Nach 6 Zyklen einer FU/FA-Chemotherapie war eine nahezu vollständige Remission des Tumors zu beobachten. Nach 2 Jahren Verlaufsbeobachtung ließ sich eine große Metastase des Siegelringzellkarzinoms im Bereich der Muskulatur des unteren Rückens nachweisen.

Dieser Fallbericht verdeutlicht die mitunter schwierige endoskopische Diagnostik von Siegelringzellkarzinomen und beschreibt einen außergewöhnlichen klinischen Verlauf.

Key words

Signet-Ring Cell Carcinoma - FU/FA Chemotherapy - Unknown Primary Location - Remission

Schlüsselwörter

Siegelringzellkarzinom - FU/FA-Chemotherapie - Unklarer Primärtumor - Remission

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