Int J Sports Med 2002; 23(1): 1-9
DOI: 10.1055/s-2002-19270
Physiology and Biochemistry

© Georg Thieme Verlag Stuttgart · New York

Variability in the Response of HDL Cholesterol to Exercise Training in the HERITAGE Family Study

A.  S.  Leon1 , S.  E.  Gaskill2 , T.  Rice3 , J.  Bergeron4 , J.  Gagnon5 , D.  C.  Rao3, 6 , J.  S.  Skinner7 , J.  H.  Wilmore8 , C.  Bouchard9
  • 1 Laboratory of Physiological Hygiene and Exercise Science, Division of Kinesiology, University of Minnesota, Minneapolis, MN, USA
  • 2 Department of Health and Human Performance, University of Montana, Missoula, MT, USA
  • 3 Division of Biostatistics, Washington University, School of Medicine, St. Louis, MO, USA
  • 4 Lipid Research Center, CHUL Research Center, Quebec, Canada
  • 5 Laboratoire de Recherche en Endocinologie Moleculaire, CHUL, Quebec, Canada
  • 6 Department of Genetics and Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
  • 7 Department of Kinesiology, Indiana University, Bloomington, IN, USA
  • 8 Department of Health and Kinesiology, Texas A & M University, College Station, TX, USA
  • 9 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
Further Information

Publication History

April 15, 2001

Publication Date:
20 December 2001 (online)

Abstract

In the HERITAGE Family Study, 675 sedentary, healthy, white and black men and women, aged 17 to 65 years, performed 20 weeks of supervised cycle ergometer exercise at the same relative intensity and weekly volume. As a group, subjects had normal mean baseline lipid levels for North Americans with the exception of below average high density lipoprotein cholesterol (HDL-C) levels. A significant mean increase in plasma HDL-C of 3.6 % was observed; however, there was marked variability in responsiveness to training, ranging from a mean 9.3 % decrease in Quartile 1 of HDL-C response to a mean 18 % increase in Quartile 4 (P < 0.0001 by ANOVA). Parallel changes in HDL2-C and HDL3-C, apolipoprotein A-I levels, and lipoprotein lipase activity were noted across quartiles. The change in HDL-C across quartiles was inversely related to baseline HDL-C (p < 0.0001) and to changes with training in plasma triglycerides (p = 0.0007). No significant differences in HDL-C response were observed across quartiles by sex, race, age, or increase in V˙O2max with training; however, weak positive associations were observed with age-adjusted education level and with reduction in abdominal fat and increase in V˙O2max at the ventilatory threshold following training. Multivariate regression analysis including baseline variables and training responses only accounted for 15.5 % of the variability in the HDL-C response to training. Thus, marked variability was found in the HDL-C response to the same endurance exercise training stimulus with only a modest amount of the response predictable by identified nongenetic factors.

References

  • 1 Baecke J AH, Burena J, Frijers J ER. A short questionnaire for the measurement of habitual physical activity in epidemiological studies.  Am J Nutr. 1982;  36 936-942
  • 2 Behnke A R, Wilmore J H. Evaluation and Regulation of Body Build and Composition. Englewood Cliffs, NY; Prentice-Hall 1974: 1-7
  • 3 Bouchard C, Leon A S, Rao D C, Skinner J S, Wilmore J H, Gagnon G. The HERITAGE Family Study. Aims, design, and measurement protocol.  Med Sci Sports Exerc. 1995;  27 721-729
  • 4 Bouchard C, Daw E W, Rice T, PeŽrusse L, Gagnon J, Province M A, Leon A S, Rao D C, Skinner J S, Wilmore J H. Familial resemblance for VO2max in the sedentary state: The HERITAGE Family Study.  Med Sci Sports Exerc. 1998;  30 252-258
  • 5 Burstein M, Samaille J. Sur un dosage rapide du cholestérol lie aux B-lipoprotéines du sérum.  J Clin Chim Acta. 1960;  5 609-610
  • 6 Davey Smith G, Neaton J D, Wentworth D, Stamler R, Stamler J. Socioeconomic differentials in mortality risk among men screened for the Multiple Risk Factor Intervention Trial. I. White men.  Am J Public Health. 1996;  86 486-496
  • 7 Després J P, Moorjani S, Tremblay A, Poehlman E T, Lupien P J, Nadeau A, Bouchard C. Heredity and changes in plasma lipids and lipoproteins after short-term exercise training in men.  Arteriosclerosis. 1988;  8 402-409
  • 8 Desbuquois B, Aurbach G D. Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays.  J Clin Endocrinol Metab. 1997;  37 732-738
  • 9 Després J P, Gagnon J, Bergeron J, Couillard C, Leon A S, Rao D C, Skinner J S, Wilmore J H, Bouchard C. Plasma post-heparin lipase activities in the HERITAGE Family Study: Gender differences and associations with lipoprotein levels.  Clin Biochem. 1999;  32 157-165
  • 10 Després J P, Gagnon J, Bergeron J, Couillard C, Leon A S, Rao D C, Skinner J S, Wilmore J H, Bouchard C. Post-heparin lipase activities in the HERITAGE Family Study: The reproducibility, gender differences and associations with lipoprotein levels.  Clin Biochem. 1999;  32 157-165
  • 11 Durstine J L, Haskell W L. Effects of exercise training on plasma lipids and lipoprotein.  Exer Sports Sci Rev. 1994;  22 477-521
  • 12 Ferland M, Després J P, Tremblay A, Pinault S, Nadeau A, Moorjani S, Lupen P J, Thebault G, Bouchard C. Assessment of adipose tissue distribution by computed axial tomography in obese women; association with body density and anthropometric measurements.  Br J Nutr. 1989;  61 139-148
  • 13 Gagnon J, Province M A, Bouchard C, Leon A S, Rao D C, Skinner J S, Wilmore J H. The HERITAGE Family Exercise Study: Quality assurance and quality control.  Am Epidemiol. 1996;  6 520-529
  • 14 Gaskill S E, Walker A J, Sanchez O A, Serfass R C, Leon A S. Validity and reliability of combining three methods to determine ventilatory threshold.  Med Sci Sports Exerc. 2001;  in Press
  • 15 Gidez L I, Miller G J, Burstein M, Slage S, Eder H H. Separation and quantitation of sub-classes of human plasma high density lipoproteins by a simple precipitation procedure.  J Lip Res. 1982;  23 1206-1223
  • 16 Hagberg J M, Ferrell R E, Katzel L I, Dengel D R, Sorkin J D, Goldberg A P. Apolipoprotein E genotype and exercise training-induced increases in plasma high-density lipoprotein (HDL)- and HDL2-cholesterol levels in overweight men.  Metabolism. 1999;  48 943-945
  • 17 Havel R J, Eder H, Bragdow H F. The distribution and chemical composition of ultra-centrifugally separated lipoproteins in human serum.  J Clin Invest. 1955;  34 1345-1353
  • 18 Kriska A M, Caspersen C J. Introduction to a collection of physical activity questionnaires.  Med Sci Sports Exer. 1997;  29 S5-S201
  • 19 Laurell C B. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.  Anal Biochem. 1966;  15 45-52
  • 20 Leon A S, Sanchez O A. Response of blood lipids and lipoproteins to exercise training alone or combined with dietary interventions.  Med Sci Sports Exerc. 2001;  33 (6 suppl) 502-515
  • 21 Leon A S, Rice T, Mandel S, DespreŽs J P, Bergeron J, Gagnon J, Rao D C, Skinner J S, Wilmore J H, Bouchard C. Blood lipid response to 20 weeks of supervised exercise in a large biracial population. The HERITAGE Family Study.  Metabolism. 2000;  49 513-520
  • 22 Meneely G R, Kaltreder N L. The volume of the lung determined by helium dilution. Description of the method and comparison with other procedures.  Am Rev Tuberculosis Pulmon Dis. 1957;  76 601-615
  • 23 National Cholesterol Education Program .Second Report of the Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. National Institutes of Health, NIH Publication 1993 No. 93 - 3095
  • 24 National Institutes of Health Consensus Development Panel on Physical Activity, and Cardiovascular Disease . Physical activity and cardiovascular health.   JAMA. 1996;  276 241-246
  • 25 Nilsson-Ehle P, Ekman R. Special assays for lipoprotein lipase and hepatic lipase activities of post-heparin plasma. In: Peters H (ed) Protides of Biological Fluids. Oxford; Pergamon Press 1978 25: 243-246
  • 26 Pasternack R C, Grundy S M, Levy D, Thompson P D. Spectrum of Risk Factors for coronary heart disease (from The 27th Bethesda conference: risk factor management for coronary disease events).  J Am Coll Cardiol. 1996;  27 978-990
  • 27 PeŽrusse L, Rice T, DespreŽs J P, Province M A, Gagnon J, Leon A S, Rao D C, Skinner J S, Wilmore J H, Bouchard C. Familial resemblance of plasma lipids, lipoprotein and hepatic lipases in the HERITAGE Family Study.  Arterioscler Thromb Vasc Biol. 1997;  127 3263-3269
  • 28 Peters J R, Quitter E S, Brekke M I, Quitter R M, Mullis R M, Braeke M L, Hunninghake D B. The Eating Pattern Assessment Tool: A simple instrument for assessing dietary fat and cholesterol intake.  J Am Diet Assoc. 1994;  94 1008-1013
  • 29 Prong N P. Short term effects of exercise on plasma lipids and lipoproteins in humans.  Sports Med. 1993;  16 431-448
  • 30 Rice T, Després J P, PeŽrusse L, Hong Y, Gagnon J, Province M, Leon A S, Skinner J S, Wilmore J H, Bouchard C, Rao D C. Familial aggregation of lipids, lipoproteins and apolipoproteins in response to 20 weeks of exercise training. The HERITAGE Family Study.  Circulation. 2001;  in press
  • 31 Ross R, Janssen I. Is abdominal fat preferentially reduced in response to exercise-induced weight loss?.  Med Sci Sports Exer. 1999;  31 S568-S572
  • 32 Skinner J S, Jaskólski A, Wilmore K, Krasnoff J, Gagnon J, Province M A, Leon A S, Rao D C, Wilmore J H, Bouchard C. Adaptation to a standardized training program and changes in fitness in a large heterogeneous population: The HERITAGE Family Study.  Med Sci Sports Exer. 2000;  32 157-161
  • 33 Sopko G, Leon A S, Jacobs D R Jr, Foster N, Moy J, Kuba K, Anderson J T, Casal D, McNally C, Frantz I. The effects of exercise and weight loss on plasma lipids in young obese men.  Metabolism. 1985;  39 227-236
  • 34 St-Amand J, Moojani S, Lupien P J, Prudhomme D, Després J P. The relation of plasma triglyceride, apolipoprotein B, and high-density lipoprotein cholesterol to postheparin lipoprotein lipase activity is dependent on apolipoprotein E polymorphism.  Metabolism. 1996;  45 261-267
  • 35 Stefanick M A. Physical activity and lipid metabolism. In: Leon AS (ed) National Institutes of Health. Physical Activity and Cardiovascular Health. A National Consensus. Champaign, IL; Human Kinetics 1997: 98-104
  • 36 Stefanick M L, Mackey S, Sheehan M, Ellsworth N, Haskell W L, Wood P D. Effects of diet and exercise in men and postmenopausal women with low levels of HDL cholesterol and high levels of LDL cholesterol.  N Engl J Med. 1998;  339 12-20
  • 37 Thompson P D, Turgalevitch S M, Glynn M M, Zmuda J M, Spannaus-Martin D J, Saratelli A, Bausserman L L, Herbert P N. Effect of prolonged exercise training without weight loss on high-density lipoprotein metabolism in overweight men.  Metabolism. 1997;  46 217-223
  • 38 Tran Z V, Weltman A, Glass G V, Mood D P. The effects of exercise on blood lipids and lipoproteins: A meta-analysis of studies.  Med Sci Sports Exer. 1983;  15 392-402
  • 39 Tukey J W. Comparing individual means in the analysis of variance.  Biometrics. 1949;  5 99-114
  • 40 Willett W C, Sampson L, Stamper M J, Rosner B, Bain C, Witschi J, Hennekins C, Speizer F E. Reproducibility and validity of a semi-quantitative food frequency questionnaire.  Am J Epidemiol. 1985;  122 51-65
  • 41 Williams P T, Stefanick M I, Vranizan K M, Wood P D. The effects of weight loss by exercise or by dieting on plasma high density lipoprotein (HDL) levels in men with low, intermediate, and normal-to-high HDL at baseline.  metabolism. 1994;  43 917-924
  • 42 Wilmore J H. A simplified method for determination of residual lung volumes.  J Appl Physiol. 1989;  27 96-100
  • 43 Wilmore J H, Després J P, Stanforth P R, Mandel S, Rice T, Gagnon J, Leon A S, Rao D C, Skinner J S, Bouchard C. Alterations in body weight and composition consequent to a 20 weeks of endurance exercise training: The HERITAGE Family Study.  Am J Clin Nutr. 1999;  70 346-352
  • 44 Wood P D, Haskell W L, Stern M P, Lewis S, Perry C. Plasma lipoprotein distributions in male and female runners.  NY Acad Sci. 1977;  301 748-763
  • 45 Wood P D, Stefanick M L, Dreon D M, Frey-Hewitt B, Garmay S C, Williams P T, Superko H R, Fortmann S P, Abers J J, Vranizan K M, Ellsworth N M, Terry R B, Haskell W L. Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise.  N Engl J Med. 1988;  319 11 73-1179
  • 46 Zmuda J M, Yurgalevitch S M, Flynn M M, Bausserman L L, Saratelli A, Spannus-Martin D J, Herbert P N, Thompson P D. Exercise training has little effect on HDL levels and metabolism in men with initially low HDL cholesterol.  Atherosclerosis. 1998;  137 215-221

 A. S. Leon, M. D.

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