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Horm Metab Res 2002; 34(2): 49-54
DOI: 10.1055/s-2002-20523
Original Basic

© Georg Thieme Verlag Stuttgart · New York

α-Tocopherol Inhibits IL-8 Synthesis Induced by Thrombin and High Glucose in Endothelial Cells

Y.  Nobata1 , M.  Urakaze1 , R.  Temaru1 , A.  Sato1 , N.  Nakamura1 , K.  Yamazaki1 , M.  Kishida1 , M.  Takata1 , M.  Kobayashi1
  • 1Toyama Medical and Pharmaceutical University, Faculty of Medicine, First Department of Internal Medicine, 2630 Sugitani, Toyama-shi, Toyama, Japan
Further Information

Publication History

19 February 2001

17 October 2001

Publication Date:
04 March 2002 (online)

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Abstract

It has been reported that α-tocopherol, an antioxidant agent, may play a role in preventing diabetic angiopathy. However, there is little evidence to show the effect of α-tocopherol on the production of pro-inflammatory cytokines in endothelial cells. Therefore, we examined the effect of α-tocopherol on the regulation of IL-8 synthesis induced by high glucose and/or thrombin in endothelial cells. Thrombin alone markedly increased the IL-8 release. Furthermore, high glucose levels and thrombin combined had additive effects on IL-8 synthesis, and α-tocopherol diminished their effect; α-tocopherol also inhibited the phosphorylation of IκB-α induced by high glucose levels and/or thrombin. Our results suggest that the administration of α-tocopherol to diabetic patients may have a beneficial effect for the prevention of diabetic vascular complications by the inhibition of IL-8 synthesis from endothelial cells.

Key words

Anti-Oxidant - High Glucose - Diabetic Angiopathy - Signal Transduction

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Masaharu Urakaze, M.D., Ph.D.

First Department of Internal Medicine · Faculty of Medicine · Toyama Medical and Pharmaceutical University

2630 Sugitani, Toyama-shi · Toyama, 930-0192 · Japan

Phone: + 81 (764) 34-7286

Fax: + 81 (764) 34-5025

Email: vascbiol-tym@umin.ac.jp

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