Horm Metab Res 2002; 34(2): 107-108
DOI: 10.1055/s-2002-20526
Letter to the Editor

© Georg Thieme Verlag Stuttgart · New York

Does Gliclazide Stimulate First-Phase, Second-Phase, or Both Phases of Insulin Release?

E.  Cerasi 1
  • 1Department of Endocrinology and Metabolism, The Hebrew University of Jerusalem, Hadassah Medical Centre, Jerusalem
Further Information

Publication History

29 October 2001

31 October 2001

Publication Date:
04 March 2002 (online)

References

  • 1 Ligtenberg J JM, Reitsma W D, van Haeften T W. Gliclazide mainly affects insulin secretion in second phase of type 2 diabetes mellitus.  Horm Metab Res. 2001;  33 361-364
  • 2 Delia Casa L, Del Rio G, Glaser B, Cerasi E. Effect of 6-month gliclazide treatment on insulin release and sensitivity to endogenous insulin in NIDDM: Role of initial continuous subcutaneous insulin infusion-induced normoglycemia.  Amer J Med. 1990;  90 37S-45S
  • 3 Cerasi E, Luft R, Efendic S. Decreased sensitivity of the pancreatic beta-cells to glucose in prediabetic and diabetic subjects. A glucose dose-response study.  Diabetes. 1972;  21 224-234
  • 4 Nesher R, Della Casa L, Litvin Y, Sinai J, Del Rio G, Pevsner B, Wax Y, Cerasi E. Insulin deficiency and insulin resistance in Type 2 (non-insulin-dependent) diabetes. Quantitative contributions of pancreatic and peripheral responses to glucose homeostasis.  Eur J Clin Invest. 1987;  17 266-274
  • 5 Steiner K E, Bowles C R, Mouton S M, Williams P E, Cherrington A D. The relative importance of first and second phase insulin secretion in countering the action of glucagon on glucose turnover in the conscious dog.  Diabetes. 1982;  31 964-972
  • 6 Getty L, Hamilton-Wessler M, Ader M, Dea M K, Bergman R N. Biphasic insulin secretion during intravenous glucose tolerance test promotes optimal interstitial insulin profile.  Diabetes. 1998;  47 1941-1947

Prof. Dr. Erol Cerasi, M.D., Ph.D.

Hadassah University Hospital

PO Box 12000 · 91120 Jerusalem · Israel

Phone: + 972 (2) 642 07 40

Fax: + 972 (2) 642 07 40

Email: Erol.Cerasi@huji.ac.il

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