In this case study, we describe the case of an 88-year-old female patient diagnosed
with Alzheimer's disease who developed a severe motor dysfunction as a side effect
of rivastigmin treatment. There have been reports on motor dysfunctions caused by
other choline esterase inhibitors.
References
- 1
Amouyal-Barkate K, Bagheri-Charabiani H, Montastruc J L, Moulias S, Vellas B.
Abnormal movements with donepezil in Alzheimer disease (letter).
Ann Pharmocother.
2000;
34
(11)
1347
- 2
Anonymous .
Cholinesterase inhibitor-induced Pisa syndrome.
International Drug Therapy Newsletter.
2000;
35
69
- 3
Arai M.
Parkinsonims onset in a patient concurrently using tiapride and donepezil.
Intern Med.
2000;
39
(10)
863
- 4
Bourke D, Druckenbrod R W.
Possible association between donepezil and worsening Parkinson's disease (letter).
Ann Pharmacother.
1998;
32
(5)
610-611
- 5
Fontan A, Fanjul S, Bartolome M, Garcia-Ruiz P, Sanchez V, De Yebenes J G.
Acetylcholinesterase inhibitors induce parkinsonism in patients with Alzheimer's disease.
Movement Disorders.
2000;
15
(3)
233
- 6
Grohmann R, Ruether E, Engel R R, Hippius H.
Assessment of Adverse Drug Reactions in Psychiatric Patients with the AMSP Drug Safety
Program.
Pharmacopsychiat.
1999;
32
21 - 28
- 7
Kwak Y T, Han I W, Baik J, Koo M S.
Relation between cholinesterase inhibitor and Pisa syndrome.
Lancet.
2000;
355
2222
- 8 Rösler M, Retz-Junginger P, Retz W. Alzheimer Demenz und Exelon. Thieme, Stuttgart
New York 1998: 38-50
Dr. Martin Heinze
Landesklinik Teupitz
Buchholzer Straße 21
15755 Teupitz
Germany
Email: heinzem@zedat.fu-berlin.de
