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TumorDiagnostik & Therapie 2002; 23(5): 182-184
DOI: 10.1055/s-2002-35213
Case Report
© Georg Thieme Verlag Stuttgart · New York

Low-Grade Myofibroblastic Sarcoma of the Chest Wall: A Rare Tumor Entity

Niedrigmalignes myofibroblastisches Sarkom der Thoraxwand: Eine seltene TumorentitätM.  J.  Utzig1 , C.  Loddenkemper2 , H.  J.  Buhr1 , P.  Schneider1
  • 1Department of General, Vascular and Thoracic Surgery, Freie Universität Berlin
  • 2Department of Pathology, Freie Universität Berlin
Further Information

Publication History

Publication Date:
31 October 2002 (online)

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Abstract

Low-grade myofibroblastic sarcoma of the chest wall is a rare tumor entity. We report a case in a 58-year-old patient in whom en-bloc resection of the tumor and reconstruction of the chest wall was performed. Initially no further adjuvant treatment was established. Due to recurrence, the patient underwent resection of the lower chest-/upper abdominal wall and pericardial resection. Low-grade myofibroblastic sarcoma arise from myofibroblasts, which have ultrastructural and physiological features of both fibroblasts and smooth muscle cells. Even though metastatic spread seems to be seldom, there is great tendency for local recurrence.

Key words

Myofibroblastic tumor - Sarcoma - Chest wall tumor

Literatur

  • 1 Mentzel T, Dry S, Katenkamp D, Fletcher C D. Low-grade myofibroblastic sarcoma: analysis of 18 cases in the spectrum of myofibroblastic tumors.  Am J Surg Pathol. 1998;  22 1228-1238
    CrossrefPubMedGoogle Scholar
  • 2 Eyden B P, Banerjee S S, Harris M, Mene A. A study of spindle cell sarcomas showing myofibroblastic differentiation.  Ultrastruct Pathol. 1991;  15 367-378
    PubMedGoogle Scholar
  • 3 Bisceglia M, Magro G. Low-grade myofibroblastic sarcoma of the salivary gland.  Am J Surg Pathol. 1999;  23 1435-1436
    PubMedGoogle Scholar
  • 4 Majno G, Gabbiani G, Hirschel B J, Ryan G B, Statkov P R. Contraction of granulation tissue in vitro: similarity to smooth muscle.  Science. 1971;  173 548-550
    PubMedGoogle Scholar
  • 5 Gabbiani G, Ryan G B, Mayne G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction.  Experientia. 1971;  27 549-550
    PubMedGoogle Scholar
  • 6 Schürch W, Seemayer T A, Gabbiani G. The myofibroblast: a quarter century after its discovery.  Am J Surg Pathol. 1998;  22 141-147
    CrossrefPubMedGoogle Scholar
  • 7 Watanabe K, Kusakabe T, Hoshi N, Saito A, Suzuki T. h-Caldesmon in leiomyosarcoma and tumors with smooth muscle cell-like differentiation: its specific expression in the smooth muscle cell tumor.  Human Pathol. 1999;  30 392-396
    PubMedGoogle Scholar
  • 8 Ceballos K M, Nielsen G P, Selig M K, O'Connell J X. Is anti-h-Caldesmon useful for distinguishing smooth muscle and myofibroblastic tumors? An immunohistochemical study.  Am J Clin Pathol. 2000;  114 746-753
    CrossrefPubMedGoogle Scholar

Paul Schneider, MD 

Dept. of General, Vascular and Thoracic Surgery, Benjamin Franklin Medical Center,
Freie Universität Berlin

Hindenburgdamm 30

12200 Berlin

Phone: + 49-30-8445-2543

Fax: + 49-30-8445-2740

Email: p.schneider@ukbf.fu-berlin.de

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