Improvement of Vitamin K Status of Breastfeeding Infants with Maternal Supplement of Vitamin K2 (MK40)

Tomizo Nishiguchi; Miwa Yamashita; Makoto Maeda; Kaoru Matsuyama; Takao Kobayashi; Naohiro Kanayama; Toshihiko Terao

doi:10.1055/s-2002-36697

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2002; 28(6): 533-538
DOI: 10.1055/s-2002-36697

Improvement of Vitamin K Status of Breastfeeding Infants with Maternal Supplement of Vitamin K2 (MK40)

Tomizo Nishiguchi¹ , Miwa Yamashita¹ , Makoto Maeda² , Kaoru Matsuyama¹ , Takao Kobayashi¹ , Naohiro Kanayama¹ , Toshihiko Terao¹

¹Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan
²Hamamatsu Medical Center Hospital, Hamamatsu, Japan

Abstract

ABSTRACT

The present study is aimed at evaluating the efficacy of maternal vitamin K2 supplementation on the vitamin K status of newborn infants using the measurement of des-gamma-carboxyprothrombin (PIVKA-II [protein induced by vitamin K absence]) and the hepaplastin test (HPT). PIVKA-II and HPT were measured at the 1st month of age in two groups: 31 infants with maternal vitamin K supplementation (15 mg/d Menatetrenone since the 14th day after parturition) (group 1) and 46 without maternal supplementation (group 2). All infants received vitamin K2 syrup twice within the 1st week of life. The PIVKA-II levels of 31 infants (group 1) were 23.6 mAU/mL (standard deviation [SD] 5.8), showing extremely low levels, and close to healthy adult levels, with a smaller deviation than what was seen in group 2. The levels of the 46 infants in group 2 were 27.8 (SD 16.0). This does not differ significantly from group 1, but a small number of infants showed a modestly high level in PIVKA-II. There also was no significant difference between the two groups in the HPT. These data would indicate that maternal vitamin K supplementation can maintain the vitamin K status throughout the late neonatal period and prevent an onset of vitamin K-deficient hemorrhage.

KEYWORD

PIVKA-ll - breast milk - vitamin K - menaquinone 4 (MK4) - hepaplastin test (HPT)

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References

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