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Horm Metab Res 2002; 34(11/12): 671-673
DOI: 10.1055/s-2002-38241
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Plasma Resistin Levels in Patients with Type 1 and Type 2 Diabetes Mellitus and in Healthy Controls

H.-C.  Fehmann1 , J.  Heyn1
  • 1Practice for Internal Medicine, Marburg, Germany
Further Information

Publication History

13 August 2002

20 November 2002

Publication Date:
27 March 2003 (online)

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Abstract

Resistin is a recently discovered hormone that is exclusively expressed in adipose tissue. Its expression in rodents was reported to be elevated or suppressed in genetic and diet-induced obesity, respectively. Resistin treatment impaired glucose tolerance and insulin action. Immunoneutralization of resistin improved insulin sensitivity, while thiazolidinedione treatment reduced resistin expression. Therefore, resistin could play a critical role in the development of obesity and type 2 diabetes. In this study were determined resistin plasma levels in humans suffering from type 1 and type 2 diabetes and in healthy controls. Plasma levels of resistin in healthy controls were 38.78 ng/ml. They were not statistically different in individuals with a broad BMI range. Resistin plasma levels in type 2 diabetes were 38.7 ng/ml, and 39.4 ng/ml in type 1 diabetes. Thiazolidinedione treatment did not influence resistin plasma levels. We conclude from our data: 1. resistin can be detected in human plasma, 2. plasma resistin levels are not different in type 1 and type 2 diabetes.

Key words

Resistin - Diabetes - Insulin Resistance - Adipose Tissue

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PD Dr. H.-C. Fehmann

Practice for Internal Medicine

Großseelheimer Str. 28 · 35039 Marburg · Germany

Phone: + 49 (64 21) 48 58 58

Fax: + 49 (64 21) 48 58 59

Email: C.Fehmann@web.de

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