Horm Metab Res 2002; 34(11/12): 764-766
DOI: 10.1055/s-2002-38243
Hypothesis
© Georg Thieme Verlag Stuttgart · New York

Aortic Carboxypeptidase-Like Protein (ACLP): What is a Protein with a Name Like That Doing in Adipose Tissue?

A.  Sorisky1 , A.  Gagnon1 , K.  Abaiian1
  • 1Departments of Medicine and Biochemistry, Microbiology & Immunology, Ottawa Health Research Institute, Ottawa Hospital, University of Ottawa, Canada
Further Information

Publication History

Received 4 October 2002

Accepted after revision 19 November 2002

Publication Date:
27 March 2003 (online)

Introduction

Aortic carboxypeptidase-like protein (ACLP) was originally cloned from aortic vascular smooth-muscle cells. It has been chosen as a subject for a hypothesis paper in this current issue of the journal due to its recent identification as a protein that is also expressed in adipose cells. Current data indicate its expression is downregulated during the early phase of the differentiation of fibroblast-like preadipose cells into mature adipose cells (adipogenesis). Remodeling the extracellular matrix (ECM) is a critical early event in adipogenesis, and ACLP may have the potential to interact with matrix components.

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Dr. A. Sorisky

Ottawa Health Research Institute

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