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Horm Metab Res 2002; 34(11/12): 726-730
DOI: 10.1055/s-2002-38262
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Gender-Specific Response to Interstitial Angiotensin II in Human White Adipose Tissue

M.  Boschmann 1 , J.  Jordan 2 , S.  Schmidt 1 , F.  Adams 2 , F.  C.  Luft 2 , S.  Klaus 1
  • 1 German Institute of Human Nutrition, Potsdam, Germany
  • 2 Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin, Medical Faculty of the Charité, Humboldt-University, Berlin, Germany
Further Information

Publication History

Received 1 October 2002

Accepted after revision 26 November 2002

Publication Date:
27 March 2003 (online)

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Abstract

Angiotensin II is synthesized locally in various tissues. However, the role of interstitial angiotensin II in the regulation of regional metabolism and tissue perfusion has not as yet been clearly defined . We characterized the effect of interstially applied angiotensin II in abdominal subcutaneous adipose tissue of young, normal-weight, healthy men (n = 8) and women (n = 6) using the microdialysis technique. Adipose tissue was perfused with 0.01, 0.1, and 1 µM angiotensin II. Dialysate concentrations of ethanol, glycerol, glucose, and lactate were measured to assess changes in blood flow (ethanol dilution technique), lipolysis, and glycolysis, respectively. Baseline ethanol ratio and dialysate lactate were both significantly higher, whereas dialysate glucose was significantly lower in men vs. women. In men, ethanol ratio and dialysate glucose, lactate and glycerol did not change significantly during perfusion with angiotensin II. In women, however, angiotensin II induced a significant increase in ethanol ratio and dialysate lactate and a decrease in dialysate glucose close to values found for men and this response was almost maximal at the lowest angiotensin II concentration used. Dialysate glycerol did not change significantly. We conclude that baseline blood flow and glucose supply and metabolism is significantly higher in women than in men. In men, interstitial Ang II has only a minimal effect on adipose tissue blood flow and metabolism. In women, however, a high physiological concentration of interstitial angiotensin II can reduce blood flow down to values found in men. This is associated with an impaired glucose supply and metabolism. Additionally, Ang II inhibits lipolysis.

Key words

Glucose - Glycerol - Lactate - Pyruvate - Microcirculation - Microdialysis

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Dr. Michael Boschmann

German Institute for Human Nutrition · WG Physiology of Energy Metabolism ·

Arthur-Scheunert-Allee 114 - 116 · 14558 Bergholz-Rehbrücke · Germany ·

Phone: + 49 (33 200) 88-430, -432

Fax: + 49 (33200) 88-500

Email: boschmann@mail.dife.de

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