Development of New Chiral Auxiliary Derived from (S)-(-)-Phenylethylamine for a Synthesis of Enantiopure (R)-2-Propyloctanoic Acid

Abstract

A new chiral auxiliary, {[(1S)-1-phenylethyl]amino}phenol, derived from (S)-(-)-1-phenylethylamine was developed for asymmetric synthesis of (R)-2-propyloctanoic acid (1) with moderate diastereoselectivity and good crystalline property.

asymmetric synthesis - chiral auxiliary - crystallinity - {[(1S)-1-phenylethyl]amino}phenol - (R)-2-propyloctanoic acid

References

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Current address: Department of Chemistry, University of Chicago, 5735 South Ellis Avenue Chicago, IL 60637, USA.

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