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Semin Respir Crit Care Med 2003; 24(3): 297-306
DOI: 10.1055/s-2003-41090
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Cor Pulmonale and Sleep-Disordered Breathing in Patients with Restrictive Lung Disease and Neuromuscular Disorders

Samuel L. Krachman1 , Gerard J. Criner2 , Wissam Chatila1
  • 1Sleep Disorders Center, Division of Pulmonary and Critical Care, Temple University School of Medicine, Philadelphia, Pennsylvania
  • 2Division of Pulmonary and Critical Care, Temple University School of Medicine, Philadelphia, Pennsylvania
Further Information

Publication History

Publication Date:
01 August 2003 (online)

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ABSTRACT

Cor pulmonale frequently develops in patients with restrictive lung disease and neuromuscular disorders. Sleep disordered breathing, including nocturnal hypoventilation and obstructive apnea, has been associated with the development of cor pulmonale and may affect morbidity. The mechanisms responsible for sleep disordered breathing include defects in the control of breathing, respiratory muscle dysfunction, and abnormalities in chest wall and lung compliance. Symptoms of disturbed sleep may allow patients with sleep disordered breathing to be appropriately diagnosed and treated, often with nocturnal ventilation, before the development of right-sided heart failure.

KEYWORDS

Cor pulmonale - rapid eye movement sleep - nocturnal hypoventilation - apnea - non-invasive ventilation

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