Download PDF
Neuropediatrics 2003; 34(6): 307-310
DOI: 10.1055/s-2003-44669
Original Article

Georg Thieme Verlag Stuttgart · New York

Vertebral Artery Dissection in an Infant: Ultrastructural Aberrations in Connective Tissue Components

K. Ogura 1 , Y. Maegaki 1 , S. Morino 2 , T. Ogawa 3 , K. Ohno 1 , A. Oka 1
  • 1Division of Child Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Tottori, Japan
  • 2Laboratory of Electron Microscopy, Faculty of Medicine, Tottori University, Tottori, Japan
  • 3Department of Radiology, Faculty of Medicine, Tottori University, Tottori, Japan
Further Information

Publication History

Received: May 1, 2003

Accepted after Revision: August 25, 2003

Publication Date:
18 December 2003 (online)

    Permissions and Reprints

Abstract

We report on a 14-month-old boy who had acute multiple infarcts in the posterior circulation due to an extremely early onset of spontaneous vertebral artery dissection. Despite the absence of clinical signs of connective tissue disorders, an ultrastructural change of collagen fibrils and elastic fibers indicated connective tissue abnormalities. Arterial dissection should be considered as a cause of stroke during infancy.

Key words

Stroke - infarction - cerebellum - collagen - elastin

References

  • 1 Brandt T, Hausser I, Orberk E, Grau A, Hartschuh W, Anton-Lamprecht I. et al . Ultrastructural connective tissue abnormalities in patients with spontaneous artery dissections.  Ann Neurol. 1998;  44 281-285
    CrossrefPubMedGoogle Scholar
  • 2 Brandt T, Orberk E, Weber R, Werner I, Busse O, Muller B T. et al . Pathogenesis of cervical artery dissections. Association with connective tissue abnormalities.  Neurology. 2001;  57 24-30
    CrossrefPubMedGoogle Scholar
  • 3 Camacho A, Villarejo A, de Aragon A M, Simon R, Mateos F. Spontaneous carotid and vertebral artery dissection in children.  Pediatr Neurol. 2001;  25 250-253
    CrossrefPubMedGoogle Scholar
  • 4 deVeber G. Cerebrovascular disease in children. Swaiman KF, Ashwal S Pediatric Neurology Principles and Practice. 3rd ed. St. Louis; Mosby 1999: 1099-1123
    Google Scholar
  • 5 Grond-Finsbach C, Klima B, Weber R, Striegel J, Fischer C, Hacke W, Brandt T, Hausser I. Exclusion mapping of the genetic predisposition for cervical artery dissections by linkage analysis.  Ann Neurol. 2002;  52 359-364
    CrossrefPubMedGoogle Scholar
  • 6 Hausser I, Anton-Lamprecht I. Differential ultrastructural aberrations of collagen fibrils in Ehlers-Danlos syndrome type I - IV as a means of diagnostics and classification.  Hum Genet. 1994;  3 394-407
    PubMedGoogle Scholar
  • 7 Khurana D S, Bonnemann C G, Dooling E C, Ouellette E M, Buonanno F. Vertebral artery dissection: issues in diagnosis and management.  Pediatr Neurol. 1996;  14 255-258
    CrossrefPubMedGoogle Scholar
  • 8 Quaglino Jr. D, Bergamini G, Boraldi F, Pasquali RI. Ultrastructural and morphometrical evaluation on normal human dermal connective tissue: the influence of age, sex and body region.  Br J Dermatol. 1996;  134 1013-1022
    CrossrefPubMedGoogle Scholar
  • 9 Salari-Namin H R, Cohen S N. Diagnosis and management of dissection. Cohen SN Management of Ischemic Stroke. New York; McGraw-Hill 2000: 277-290
    Google Scholar
  • 10 Schievink W I, Morki B, O'Fallon W M. Recurrent spontaneous cervical-artery dissection.  N Eng J Med. 1994;  330 393-397
    CrossrefPubMedGoogle Scholar
  • 11 Schievink W I, Morki B, Piepgras D G. Spontaneous dissections of cervicocephalic arteries in childhood and adolescence.  Neurology. 1994;  44 1607-1612
    CrossrefPubMedGoogle Scholar
  • 12 Schievink W I. Spontaneous dissection of the carotid and vertebral arteries.  N Eng J Med. 2001;  344 898-906
    Google Scholar

M. D. Kaeko Ogura

Division of Child Neurology
Institute of Neurological Sciences
Faculty of Medicine
Tottori University

36 - 1 Nishicho

Yonago

Tottori 683-8504

Japan

Email: oguran@grape.med.tottori-u.ac.jp

      >