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Z Gastroenterol 2004; 42(3): 269-275
DOI: 10.1055/s-2004-812833
Übersicht
© Karl Demeter Verlag im Georg Thieme Verlag Stuttgart · New York

13C-basierte Atemtests in der Leberfunktionsdiagnostik

13C-Breath Tests for the Assessment of Liver FunctionA. R. J. Schneider1 , W. F. Caspary1 , J. Stein1
  • 1Medizinische Klinik II (Direktor: Prof. Dr. W. F. Caspary), Johann-Wolfgang-Goethe-Universität Frankfurt
Further Information

Publication History

Manuskript eingetroffen: 26.9.03

Manuskript akzeptiert: 13.1.04

Publication Date:
15 March 2004 (online)

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Zusammenfassung

Konventionelle laborchemische Surrogatparameter geben indirekte Hinweise auf den Metabolismus oder die Syntheseleistung hepatischer Zellsysteme. 13C-basierte Atemtests erweitern das diagnostische Spektrum um die Aussicht, Enzymsysteme und medikamentöse Interaktionen relativ gezielt nichtinvasiv charakterisieren zu können. Wir geben einen Überblick über die bisher verfügbaren verschiedenen Testsysteme sowie den möglichen Stellenwert in der hepatologischen Diagnostik.

Abstract

Routine work-up of hepatic diseases is performed by regular laboratory tests which indicate changes in the metabolic capacity of various hepatic cellular systems. A 13C-based breath test may offer further selective characterisation of hepatic enzymes by means of a non-invasive technique. We present an overview on current test systems and their potential relevance in the assessment of hepatic diseases.

Schlüsselwörter

Leberfunktion - Atemtest - stabile Isotope - Hepatitis - Leberzirrhose - Fibrose

Key words

Liver function - breath test - stable isotopes - hepatitis - liver cirrhosis - fibrosis

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Jürgen Stein

Medizinische Klinik II, Johann-Wolfgang-Goethe-Universität Frankfurt

Theodor-Stern-Kai 7

60590 Frankfurt/Main

Email: J.Stein@em.uni-frankfurt.de

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