TumorDiagnostik & Therapie 2004; 25(4): 169-170
DOI: 10.1055/s-2004-813469
Symposium Report

© Georg Thieme Verlag KG Stuttgart · New York

Aktueller Stand der Diagnostik gastrointestinaler Stromatumoren aus der Sicht der Pathologie

Diagnostic of Gastrointestinal Stromal Tumors - From a Pathologit's PerspectiveE. Wardelmann1
  • 1Institut für Pathologie, Universitätsklinikum Bonn
Further Information

Publication History

Publication Date:
23 August 2004 (online)

  • 1 Kindblom L G, Remotti H E, Aldenborg F. et al . Gastrointestinal pacemaker cell tumor (GIPACT) - Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal.  Am J Pathol. 1998;  152 1259-1269
  • 2 Miettinen M, Monihan J M, Sarlomo-Rikala M. et al . Gastrointestinal stromal tumors/smooth muscle tumors (GIST) primary in the omentum and mesentery: clinicopathological and immunohistochemical study of 26 cases.  Am J Surg Pathol. 1999;  23 1109-1118
  • 3 Fletcher C D, Berman J, Corless C L. et al . Diagnosis of gastrointestinal stromal tumors: A consensus approach.  Hum Pathol. 2002;  33 459-465
  • 4 Miettinen M, El-Rifai W, Sobin L H. et al . Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review.  Hum Pathol. 2002;  33 478-483
  • 5 Hirota S, Isozaki K, Moriyama Y. et al . Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.  Science. 1998;  279 577-580
  • 6 Wardelmann E, Losen I, Hans V. et al . Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors.  Int J Cancer. 2003;  106 887-895
  • 7 Heinrich M C, Corless C L, Duensing A. et al . PDGFRA activating mutations in gastrointestinal stromal tumors.  Science. 2003;  299 708-710
  • 8 Hirota S, Ohashi A, Nishida T. et al . Gain-of-function mutations in platelet-derived growth factor receptor a gene in gastrointestinal stromal tumors.  Gastroenterology. 2003;  125 660-667
  • 9 Wardelmann E, Hrychyk A, Merkelbach-Bruse S. et al . Association of platelet-derived growth factor receptor alpha mutations with gastric primary site and epithelioid or mixed cell morphology in gastrointestinal stromal tumors.  J Mol Diagn. 2004 (in press); 
  • 10 Wardelmann E, Neidt I, Bierhoff E. et al . c-kit mutations in gastrointestinal stromal tumors occur preferentially in the spindle rather than in the epithelioid cell variant.  Mod Pathol. 2002;  15 125-136
  • 11 Heinrich M C, Corless C L, Demetri G D. et al . Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumors.  J Clin Oncol. 2003;  21 4342-4349
  • 12 Debiec-Rychter M, Dumez H, Judson I. et al . Use of c-kit/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group.  Eur J Cancer. 2004;  40 689-695

PD Dr. med. Eva Wardelmann

Institut für Pathologie, Universitätsklinikum Bonn

Postfach 2120

53011 Bonn

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