BOLD Magnetic Resonance Imaging of Skeletal Muscle

Michael D. Noseworthy; Daniel P. Bulte; Jeff Alfonsi

doi:10.1055/s-2004-815678

Seminars in Musculoskeletal Radiology, Table of Contents

Semin Musculoskelet Radiol 2003; 7(4): 307-316
DOI: 10.1055/s-2004-815678

BOLD Magnetic Resonance Imaging of Skeletal Muscle

Michael D. Noseworthy^1,2,3 , Daniel P. Bulte² , Jeff Alfonsi⁴

¹Department of Radiology, , McMaster University
²Department of Medical Physics and Radiation Sciences, McMaster University, Hamilton, Ontario, Canada
³The University of Toronto, Department of Medical Imaging, Toronto, Ontario, Canada
⁴The Hospital for Sick Children, Department of Diagnostic Imaging, Imaging Physics, Toronto, ON Canada

Abstract

ABSTRACT

Blood-oxygen-level-dependent (BOLD) imaging was a concept introduced in 1990 for evaluating brain activation. The method relies on magnetic resonance imaging (MRI) contrast resulting from changes in the microvascular ratio of oxyhaemoglobin (oxyHb) to deoxyhaemoglobin (deoxyHb). OxyHb is diamagnetic, whereas deoxyHb is paramagnetic, which produces a local bulk magnetic susceptibility effect and subsequent MRI signal change. The changes are typically observed in T ₂*-weighted functional MRI scans. However, there has recently been interest in BOLD as a way to evaluate microcirculation of any normal or diseased tissue. This review focuses on the application of BOLD imaging in the understanding of normal and diseased skeletal muscle. In addition we present new findings showing the possible application of BOLD imaging with hyperoxia for evaluating skeletal muscle physiology.

KEYWORDS

Muscle - MRI - BOLD

Full Text

References

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