Neuropediatrics 2004; 35(5): 279-282
DOI: 10.1055/s-2004-821301
Original Article

Georg Thieme Verlag KG Stuttgart · New York

Diffusion-Weighted Imaging Findings in Juvenile Metachromatic Leukodystrophy[1]

K. K. Oguz1 , B. Anlar2 , N. Senbil3 , A. Cila1
  • 1Department of Radiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • 2Department of Pediatric Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • 3Dr. Sami Ulus Children's Hospital, Ankara, Turkey
Further Information

Publication History

Publication Date:
08 November 2004 (online)

Abstract

Magnetic resonance (MR) imaging has an important role in the diagnosis of metachromatic leukodystrophy (MLD). We report diffusion-weighted MR imaging (DWI) findings of four cases of juvenile type MLD. DWI showed restricted diffusion lines with greater areas of increased diffusion in three patients and widespread increased diffusion in one patient. This variability in DWI findings can be related to the histological stage of the disease at the time of imaging, ranging from intracellular metachromatic material accumulation to breakdown of myelin membranes.

1 Presented in part at the American Society of Neuroradiology Meeting 2004, Seattle, USA

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1 Presented in part at the American Society of Neuroradiology Meeting 2004, Seattle, USA

MD Banu Anlar

Department of Pediatric Neurology, Faculty of Medicine, Hacettepe University

06100 Ankara

Turkey

Email: banlar@hacettepe.edu.tr

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