Abstract
The aim of this study was to determine wether continuous heavy physical activities
as well as lack of food and sleep during military training (three weeks of conditioning
followed by a five-day combat course) alter serum concentrations of IGF-I and/or its
binding proteins, evaluating the relationship to metabolic changes. Before and after
training, we measured serum levels of both total and free IGF-I, IGFBP-1 and IGFBP-3
as well as plasma levels of branched-chain amino acids (valine, leucine and isoleucine)
and glucose from 26 cadets (21 ± 2 yr). Total and free IGF-I levels were decreased
after training from 228 ± 12 to 160 ± 7 ng/ml and from 0.80 ± 0.08 to 0.52 ± 0.06
ng/ml, p < 0.001 respectively) as well as IGFBP-3 (p < 0.001), while IGFBP-1 levels
were increased (p < 0.001). BCAA levels were decreased from 245.4 ± 7.5 to 215.9 ±
5.1 µmol/l, p < 0.001, while those of glucose remained unchanged. There were correlations
between changes in total IGF-I and IGFBP-3 (p < 0.05) and between free IGF-I and IGFBP-1
(p < 0.01). Several correlations appeared between changes in all the components of
the IGF-I axis and branched-chain amino acids. We concluded that responses of the
IGF-I system during an intense training could represent an adaptative response to
the encountered energy deficiency, resulting a diversion of substrate from growth
to acute metabolic needs.
Key words
Intense training · IGF-I · IGFBP-1 · IGFBP-3 · Metabolic parameters
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D. Gomez-Merino
Department of Physiology
IMASSA · B.P.73 · 91223 Brétigny-sur-Orge Cedex · France
Phone: + 33/1/6923-7729
Fax: + 33/1/6923-7002
Email: dgomez@imassa.fr