Blutbildveränderungen unter Antipsychotika der zweiten Generation

Zusammenfassung

Die Gefahr schwerer Blutbildveränderungen stellt einen limitierenden Faktor in der Behandlung mit Clozapin dar. Durch die Entwicklung moderner Antipsychotika der zweiten Generation ist es heute aber möglich, die positiven Effekte dieser Medikamentengruppe zu nutzen, ohne die Risiken einer Clozapin-Behandlung eingehen zu müssen. Allerdings existiert eine Reihe von Kasuistiken, die zeigen, dass auch unter einer Behandlung mit Antipsychotika der zweiten Generation schwere Blutbildveränderungen auftreten können. Die vorliegende Arbeit gibt eine Übersicht über die bisher publizierten Fallberichte und diskutiert die Konsequenzen für die tägliche klinische Praxis.

Abstract

The danger of severe haematological abnormalities limits the use of clozapine in the treatment of psychoses. The development of modern second generation antipsychotics such as olanzapine, risperidone, quetiapine, amisulpride, ziprasidone or aripiprazol, however, makes it possible to use the positive effects of this class of drugs without the risks of a clozapine treatment. Nevertheless, there are several case reports about severe haematological abnormalities even during treatment with these second generation antipsychotics. This review summarises recently published cases and discusses the consequences for the daily clinical work.

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