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Semin Respir Crit Care Med 2004; 25: 17-27
DOI: 10.1055/s-2004-829641
Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Therapy

Janessa J. Laskin1 , Alan B. Sandler2
  • 1Division of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada
  • 2Department of Medical Oncology, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee
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Publikationsverlauf

Publikationsdatum:
22. Juni 2004 (online)

    Lizenzen und Reprints

Over the past decade our evolving knowledge and understanding of cancer biology has allowed rapid progression in the development of targeted cancer therapy. Improving lung cancer mortality has remained a difficult task; however, therapeutic agents directed against the epidermal growth factor receptor (EGFR) have provided physicians with a valuable new tool to integrate into multimodality therapy. EGFR inhibitors have been shown to elicit meaningful antitumor effects and quality-of-life benefits with acceptable toxicity. The rationale, utility, toxicity profile, and therapeutic strategy of EGFR-targeted therapy will be reviewed.

KEYWORDS

Epidermal growth factor receptor (EGFR) - non-small cell lung cancer (NSCLC) - tyrosine kinase inhibitors - ZD1839 - OSI-774 - IMC-C225

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Janessa LaskinM.D. 

Division of Medical Oncology, BC Cancer Agency, 600 W. 10th Ave., Vancouver

BC, V5Z-4E6, Canada

eMail: jlaskin@bccancer.bc.ca

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