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Semin Thromb Hemost 2004; 30(4): 427-439
DOI: 10.1055/s-2004-833478
Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Protein-Protein Interactions in Platelet αIIbβ3 Signaling

Charito S. Buensuceso1 , 2 , Elena G. Arias-Salgado2 , Sanford J. Shattil2
  • 1Assistant Professor, Division of Hematology-Oncology, Department of Medicine, University of California San Diego, La Jolla, California
  • 2Division of Vascular Biology, Department of Cell Biology, and the Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California
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Publication History

Publication Date:
08 September 2004 (online)

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The major platelet integrin αIIbβ3 is the main receptor involved in platelet functions such as aggregation and spreading on extracellular matrix. Like all other integrins, αIIbβ3 is capable of transducing signals both from inside and outside of the cell. To mediate these functions, αIIbβ3 interacts with intracellular and transmembrane proteins. The identification of these proteins, as well as the study of their functions, has provided valuable insights into integrin-mediated function and signaling. This review summarizes the known proteins that directly interact with αIIbbβ3 and provides an overview of their roles in integrin function.

KEYWORDS

Integrin αIIbβ3 - platelets - signaling

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 Dr.
Sanford J Shattil

Department of Medicines, University of California San Diego, Leichtag Biomedical Research Building

9500 Gilman Drive, MC 0726

La Jolla, CA 92093

Email: shattil@scripps.edu

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