Pulmonary Amyloidosis in Hematological Disorders

Jean-François Cordier

doi:10.1055/s-2005-922033

Seminars in Respiratory and Critical Care Medicine, Table of Contents

Semin Respir Crit Care Med 2005; 26(5): 502-513
DOI: 10.1055/s-2005-922033

Pulmonary Amyloidosis in Hematological Disorders

Jean-François Cordier¹

¹Claude Bernard University, Department of Respiratory Medicine-Reference Center for Orphan Pulmonary Diseases, Louis Pradel University Hospital, Lyon (Bron), France

Abstract

ABSTRACT

Amyloidosis is defined by tissue deposits of amyloid, a proteic substance with a characteristic spatial structure of β-sheet fibrils assembled into bundles. This structure results in specific staining with Congo red dye, with green birefringence under polarized light microscope. AL amyloid forms from amyloidogenic immunoglobulins produced by clonal plasma cells. Pulmonary amyloidosis may be either part of systemic amyloidosis (primary amyloidosis or associated with myeloma) or organ-limited.

Pulmonary interstitial amyloidosis in systemic amyloidosis is rarely symptomatic unless amyloid deposits severely affect gas exchange alveolar structures, thus resulting in serious respiratory impairment. Localized parenchymal involvement may present as nodular amyloidosis or as amyloid deposits in the vicinity of pulmonary lymphomas. Tracheobronchial amyloidosis, which is not associated with evident clonal proliferation, results in airway stenoses necessitating iterative laser treatment.

Treatment of systemic amyloidosis aims at reducing the clonal cell populations producing amyloidogenic immunoglobulins, using high-dose chemotherapy followed by autologous stem cell transplantation in carefully selected patients. Its efficiency in treating diffuse pulmonary amyloidosis has not been established.

KEYWORDS

Amyloidosis - interstitial lung disease - pulmonary nodule - tracheobronchial stenosis

Full Text

References

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Jean-François CordierM.D.

Claude Bernard University, Department of Respiratory Medicine-Reference Center for Orphan Pulmonary Diseases

Louis Pradel University Hospital, 28 avenue du Doyen Lépine

69677 Lyon (Bron), France

Email: jean-francois.cordier@chu-lyon.fr