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Neuropediatrics 2006; 37(3): 130-136
DOI: 10.1055/s-2006-924554
Original Article

Georg Thieme Verlag KG Stuttgart · New York

Interleukin-10 High Producer Allele and Ultrasound-Defined Periventricular White Matter Abnormalities in Preterm Infants: A Preliminary Study

M. Dördelmann1 , J. Kerk2 , F. Dressler1 , M.-J. Brinkhaus3 , D. B. Bartels4 , C. E. L. Dammann1 , 5 , T. Dörk[*] 2 , O. Dammann[*] 3 , 6
  • 1Dept. of Pediatric Pneumology and Neonatology, OE 6710, Hannover Medical School, Hannover, Germany
  • 2Dept. of Gynecology and Obstetrics, OE 6410, Hannover Medical School, Hannover, Germany
  • 3Perinatal Infectious Disease Epidemiology Unit, OE 6415, Hannover Medical School, Hannover, Germany
  • 4Dept. of Epidemiology, Social Medicine and Health System Research, Hannover Medical School, Hannover, Germany
  • 5Newborn Medicine, Dept. of Pediatrics, Tufts New England Medical Center, Boston, MA, USA
  • 6Neuroepidemiology Unit, Depts. of Neurology, Children's Hospital and Harvard Medical School, Boston, MA, USA
Further Information

Publication History

Received: February 26, 2006

Accepted after Revision: August 8, 2006

Publication Date:
11 September 2006 (online)

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Abstract

Objectives: Inflammation plays a role in prematurity, in neonatal disorders of the brain, lung, eye, bowel, and in developmental disability among preterm infants. We initiated a pilot study in preterm children to determine the prevalence of single nucleotide polymorphisms (SNPs) in the infection/inflammation-associated genes for interleukin (IL)-10 (- 1082 G/A), IL-1β (+ 3953 C/T), tumor necrosis factor (TNF)-α (- 308 G/A) and toll-like receptor 4 (TLR-4) (Asp299Gly) and whether these SNPs affect the risk for neonatal disorders. Study Design: We genotyped 73 children ≥ 2 years of age whose gestational age at birth was < 32 weeks, and explored the associations between genotypes and neonatal disorders and developmental status at age 2 + years. Results: Infants homozygous for the high IL-10 producer - 1082 G‐allele (n = 15) were significantly less likely to develop ultrasound-defined periventricular echodensities. A non-significant, but prominent, risk reduction for bronchopulmonary dysplasia, high-grade retinopathy, cerebral palsy, and developmental delay at age 2 + years was present. Polymorphisms in the IL-1β, TNF-α, and TLR-4 genes were too infrequent in our pilot sample to allow for reasonable analysis. Conclusion: Infants homozygous for the IL-10 high producer - 1082 G allele might be at reduced risk for prematurity-associated disorders.

Key words

Infant - premature - brain - cytokine - polymorphism

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1 These two authors contributed equally

MD Michael Dördelmann

Department of Pediatric Pneumology and Neonatology
OE 6710
Hannover Medical School

30623 Hannover

Germany

Email: doerdelmann.michael@mh-hannover.de

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