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Semin Thromb Hemost 2006; 32(3): 295-304
DOI: 10.1055/s-2006-939442
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Thrombopoietin and Platelet Function

Jan Willm N. Akkerman1
  • 1Professor, Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
Further Information

Publication History

Publication Date:
02 May 2006 (online)

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ABSTRACT

In hematopoietic stem cells and megakaryocytes, the thrombopoietin (TPO) receptor signals to control proliferation, maturation, and antiapoptosis. In the anucleated platelet, much of this signaling appears out of place. Nevertheless, platelets possess TPO receptors and the cascades for transduction of TPO signals, but the final effect has shifted from DNA regulation to control of platelet aggregation and secretion. Although at physiological concentrations, TPO is not a sufficiently strong stimulator to trigger platelet functions in the absence of a second stimulator, TPO increases the sensitivity of platelets to agonist stimulation, leading to better functions at lower stimulation.

KEYWORDS

Thrombopoietin - megakaryocytes - platelets - hematopoietic progenitor - priming - signaling - Janus kinase - Ras - protein kinase B - Stat - adhesion - aggregation - secretion

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Jan Willm N AkkermanPh.D. 

University Medical Center Utrecht, Thrombosis and Haemostasis Laboratory, Department of Haematology (G03.647)

P.O. Box 85500, 3508 GA Utrecht, The Netherlands

Email: j.w.n.akkerman@lab.azu.nl

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