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Synthesis 2006(17): 2855-2864
DOI: 10.1055/s-2006-942535
DOI: 10.1055/s-2006-942535
PAPER
© Georg Thieme Verlag Stuttgart · New YorkA Suzuki-Miyaura Approach to a Series of Forensically Relevant Pyridines
Further Information
Received
27 February 2006
Publication Date:
02 August 2006 (online)
Publication History
Publication Date:
02 August 2006 (online)
Abstract
A convenient and general method for the preparation of sixteen 3,5-diarylsubstituted 2,4- and 2,6-dimethylpyridines of high forensic importance is described. The Suzuki cross-coupling reaction between a range of ring-substituted phenylboronic acids and 3,5-dibromo-2,4-dimethylpyridine and 3,5-dibromo-2,6-dimethylpyridine was used as a key step.
Key words
cross-coupling reactions - heterocycles - chemoselectivity - amphetamine analogues - route-specific by-products
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References
Considering the fact that conversion of aryl halide was 100%, the yield was calculated by the comparison of the peak area of the products with the sum of peak areas recorded for major by-products.