Synthesis 2006(17): 2855-2864  
DOI: 10.1055/s-2006-942535
PAPER
© Georg Thieme Verlag Stuttgart · New York

A Suzuki-Miyaura Approach to a Series of Forensically Relevant Pyridines

Dariusz Błachuta, Zbigniew Czarnocki*b, Krystyna Wojtasiewiczb
a Department of Criminalistics, Internal Security Agency, 1 Sierpnia 30A, 02-134 Warsaw, Poland
b Faculty of Chemistry, Warsaw University, Pasteura 1, 02-093 Warsaw, Poland
Fax: +48(22)8225996; e-Mail: czarnoz@chem.uw.edu.pl;
Further Information

Publication History

Received 27 February 2006
Publication Date:
02 August 2006 (online)

Abstract

A convenient and general method for the preparation of sixteen 3,5-diarylsubstituted 2,4- and 2,6-dimethylpyridines of high forensic importance is described. The Suzuki cross-coupling reaction between a range of ring-substituted phenylboronic acids and 3,5-dibromo-2,4-dimethylpyridine and 3,5-dibromo-2,6-dimethylpyridine was used as a key step.

28

Considering the fact that conversion of aryl halide was 100%, the yield was calculated by the comparison of the peak area of the products with the sum of peak areas recorded for major by-products.