A Suzuki-Miyaura Approach to a Series of Forensically Relevant Pyridines

Dariusz Błachut; Zbigniew Czarnocki; Krystyna Wojtasiewicz

doi:10.1055/s-2006-942535

PAPER

A Suzuki-Miyaura Approach to a Series of Forensically Relevant Pyridines

Dariusz Błachut^a, Zbigniew Czarnocki*^b, Krystyna Wojtasiewicz^b
^a Department of Criminalistics, Internal Security Agency, 1 Sierpnia 30A, 02-134 Warsaw, Poland
^b Faculty of Chemistry, Warsaw University, Pasteura 1, 02-093 Warsaw, Poland
Fax: +48(22)8225996; e-Mail: czarnoz@chem.uw.edu.pl;

Abstract

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Abstract

A convenient and general method for the preparation of sixteen 3,5-diarylsubstituted 2,4- and 2,6-dimethylpyridines of high forensic importance is described. The Suzuki cross-coupling reaction between a range of ring-substituted phenylboronic acids and 3,5-dibromo-2,4-dimethylpyridine and 3,5-dibromo-2,6-dimethylpyridine was used as a key step.

Key words

cross-coupling reactions - heterocycles - chemoselectivity - amphetamine analogues - route-specific by-products

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References

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