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Semin Neurol 2006; 26(5): 523-530
DOI: 10.1055/s-2006-951625
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Genetics of Ischemic Stroke: Future Clinical Applications

Michael M. Wang1
  • 1Departments of Neurology and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan
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Publication History

Publication Date:
17 October 2006 (online)

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ABSTRACT

Ischemic stroke has long been thought to have a genetic component that is independent of conventional vascular risk factors. It has been estimated that over one half of stroke risk is determined by inherited genes. However, until recently, strong evidence of genetic influence on ischemic stroke has been subject to criticism because the risk factors for stroke are also inherited and because previous studies suffered from limitations imposed by this highly heterogeneous neurological disorder. Recent advances in molecular genetics have led to the identification of specific genetic loci that impart susceptibility to ischemic stroke. We review the studies of these genes and discuss the future potential applications of genetic markers on the management of ischemic stroke patients.

KEYWORDS

Stroke - genetics - CADASIL - PDE4D - ALOX5AP

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Michael M WangM.D. Ph.D. 

7629 Med Sci II, Box 0622

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