Zusammenfassung
Eine Vielzahl unterschiedlicher Erkrankungen kann sich mit bilateralen Thalamusläsionen
manifestieren. Dazu gehören einerseits vaskuläre Erkrankungen, die eine möglichst
rasche therapeutische Intervention erfordern, wie z. B. die Basilarisspitzenembolie
und die innere Hirnvenenthrombose, sowie andererseits auch Tumoren, infektiöse oder
demyelinisierende Erkrankungen sowie metabolisch-toxische Veränderungen. Eine detaillierte
Kenntnis der typischen bildgebenden Befunde der verschiedenen Krankheitsbilder ist
daher für eine aussagekräftige radiologische Diagnose unerlässlich. Die vorliegende
Arbeit gibt einen Überblick über die radiologischen Befunde der wichtigsten bithalamischen
Erkrankungen und liefert eine aktuelle Literaturübersicht zu diesem Thema.
Abstract
A multitude of different diseases can result in bilateral thalamic lesions. These
include vascular pathologies requiring prompt therapeutic intervention, such as basilar
thrombosis or thrombosis of the internal cerebral veins, as well as tumors, infectious
or demyelinating diseases, and toxic-metabolic lesions. Therefore, detailed knowledge
of the typical radiological findings for the various diseases is essential for determining
the correct diagnosis. This review provides a synopsis of the radiological findings
for the most important bithalamic lesions and an overview of the literature.
Key words
thalamus - bilateral lesions - MRI
Literatur
- 1 Danek A. Sonderfall bilateral-symmetrische Infarkte. Hamann GF, Siebler M, von Scheidt
W Schlaganfall Landsberg; ecomed 2002: 189-198
- 2
Schmahmann J D.
Vascular syndromes of the thalamus.
Stroke.
2003;
34
2264-2278
- 3
Weidauer S, Nichtweiß M, Zanella F E. et al .
Assessment of paramedian thalamic infarcts: MR imaging, clinical features and prognosis.
Eur Radiol.
2004;
14
1615-1626
- 4
Tatu L, Moulin T, Bogousslavsky J. et al .
Arterial territories of the human brain: Cerebral hemispheres.
Neurology.
1998;
50
1699-1708
- 5
Bogousslavsky J, Regli F, Assal G.
The syndrome of unilateral tuberothalamic artery territory infarction.
Stroke.
1986;
17
434-441
- 6
Percheron G.
Arteries of the human thalamus. II. Arteries and paramedian thalamic territory of
the communicating basilar artery.
Rev Neurol (Paris).
1976;
132
309-324
- 7
Caplan L R.
„Top of the basilar” syndrome.
Neurology.
1980;
30
72-79
- 8
Roitberg B Z, Tuccar E, Alp M S.
Bilateral paramedian thalamic infarct in the presence of an unpaired thalamic perforating
artery.
Acta Neurochir (Wien).
2002;
144
301-304
- 9
Chan S, Kartha K, Yoon S S. et al .
Multifocal hypointense cerebral lesions on gradient-echo MR are associated with chronic
hypertension.
AJNR Am J Neuroradiol.
1996;
17
1821-1827
- 10
Imaizumi T, Horita Y, Chiba M. et al .
Dot-like hemosiderin spots on gradient echo T2*-weighted magnetic resonance imaging
are associated with past history of small vessel disease in patients with intracerebral
hemorrhage.
J Neuroimaging.
2004;
14
251-257
- 11
Liebetrau M, Mayer T E, Brüning R. et al .
Intra-arterial thrombolysis of complete deep cerebral venous thrombosis.
Neurology.
2004;
63
2444-2445
- 12
Peeters E, Stadnik T, Bissay F. et al .
Diffusion weighted MR imaging of an acute venous stroke: case report.
AJNR Am J Neuroradiol.
2001;
22
1949-1952
- 13
Ducreux D, Oppenheim C, Vandamme X. et al .
Diffusion-weighted imaging patterns of brain damage associated with cerebral venous
thrombosis.
AJNR Am J Neuroradiol.
2001;
22
261-268
- 14
Greenough G P, Mamourian A, Harbaugh R E.
Venous hypertension associated with a posterior fossa dural arteriovenous fistula:
another cause of bithalamic lesions on MR images.
AJNR Am J Neuroradiol.
1999;
20
145-147
- 15
Tanaka K, Marooka Y, Nakagawa Y. et al .
Dural arteriovenous malformation manifesting as dementia due to ischemia in bilateral
thalami. A case report.
Surg Neurol.
1999;
51
489-493
- 16
Tihan T, Burger P C, Pomper M. et al .
Subacute diencephalic angioencephalopathy: biopsy diagnosis and radiological features
of a rare entity.
Clin Neurol Neurosurg.
2001;
103
160-167
- 17
Cheek W R, Taveras J M.
Thalamic tumors.
J Neurosurg.
1966;
24
505-513
- 18
Partlow G D, del Carpio O DR, Melanson D. et al .
Bilateral thalamic glioma: review of eight cases with personality change and mental
detoriation.
AJNR Am J Neuroradiol.
1992;
13
1225-1230
- 19
Estève F, Grand S, Rubin C. et al .
MR spectroscopy of bilateral thalamic gliomas.
AJNR Am J Neuroradiol.
1999;
20
876-881
- 20
Hirano H, Yokoyama S, Nakayama M. et al .
Bilateral thalamic glioma: case report.
Neuroradiology.
2000;
42
732-734
- 21
Lichy M P, Bachert P, Hamprecht F. et al .
Einsatz der 1H-MR-spektroskopischen Bildgebung in der Strahlentherapie: Cholin als Marker für die
Bestimmung der relativen Wahrscheinlichkeit eines Tumorprogresses nach Bestrahlung
glialer Hirntumoren.
Fortschr Röntgenstr.
2006;
178
627-633
- 22
Erdogan C, Hakyemez B, Yildirim N. et al .
Brain abscess and cystic brain tumor: discrimination with dynamic susceptibility contrast
perfusion-weighted MRI.
J Compu Assist Tomogr.
2005;
29
663-667
- 23
Di Costanzo A, Scarabino T, Trojsi F. et al .
Multiparametric 3T MR approach to the assessment of cerebral gliomas: tumor extent
and malignancy.
Neuroradiology.
2006;
48
622-631
- 24
Smyth E G, Stern K.
Tumors of the thalamus: a clinico-pathological study.
Brain.
1938;
61
339-374
- 25
Burger P C, Cohan P C, Rosenblum M K. et al .
Pathology of diencephalic astrocytomas.
Pediatr Neurosurg.
2000;
32
214-219
- 26
Rauscher A, Sedlacik J, Fitzek C. et al .
Bestimmung des Einflusses eines gasförmigen Kontrastmittels auf zerebrale Tumoren
mittels hochaufgelöster suszeptibilitätsgewichteter MR-Bildgebung.
Fortschr Röntgenstr.
2005;
177
1065-1069
- 27
Kim D I, Yoon P H, Ryu Y H. et al .
MRI of germinomas arising from the basal ganglia and thalamus.
Neuroradiology.
1998;
40
507-511
- 28
Kalita J, Misra U K.
Comparison of CT scan and MRI findings in the diagnosis of Japanese encephalitis.
J Neurol Sci.
2000;
174
3-8
- 29
Petropoulou K A, Gordon S M, Prayson R A. et al .
West Nile virus meningo-encephalitis: MR imaging findings.
AJNR Am J Neuroradiol.
2005;
26
1986-1995
- 30
Deresiewicz R L, Thaler S J, Shu L. et al .
Clinical and neuroradiographic manifestations of Eastern equine encephalitis.
N Engl J Med.
1997;
336
1867-1874
- 31
Johkura K, Momoo T, Kuroiwa Y.
Thalamic involvement of Epstein-Barr virus encephalitis demonstrated by MRI.
J Neurol.
2003;
250
357-358
- 32
Schankin C J, Birnbaum T, Linn J. et al .
A fatal encephalitis.
Lancet.
2005;
365
358
- 33
Hähnel S, Storch-Hagenlocher B, Kress B. et al .
Infektiöse Erkrankungen des Hirnparenchyms bei Erwachsenen: Bildgebung und differenzialdiagnostische
Aspekte.
Fortschr Röntgenstr.
2005;
177
1349-1365
- 34
Vercellino M, Plano F, Votta B. et al .
Grey matter pathology in multiple sclerosis.
J Neuropathol Exp Neurol.
2005;
64
1101-1107
- 35
Garg R K.
Acute disseminated encephalomyelitis.
Postgrad med J.
2003;
79
11-17
- 36
Prayer L, Wimberger D, Kramer J. et al .
Cranial MRI in Wilson’s disease.
Neuroradiology.
1990;
32
211-214
- 37
King A D, Walshe J M, Kendall B E. et al .
Cranial MR imaging in Wilson’s disease.
AJR Am J Roentgenol.
1996;
167
1579-1584
- 38
Sener R N.
Diffusion MR imaging changes associated with Wilson disease.
AJNR Am J Neuroradiol.
2003;
24
965-967
- 39
Vymazal J, Babis M, Brooks R A. et al .
T1 and T2 alterations in the brains of patients with hepatic cirrhosis.
AJNR Am J Neuroradiol.
1996;
17
333-336
- 40
Zeidler M, Sellar R J, Collie D A. et al .
The pulvinar sign on magnetic resonance imaging in variant Creutzfeldt-Jakob disease.
Lancet.
2000;
355
1412-1418
- 41
Collie D A, Summers D M, Sellar R J. et al .
Diagnosing variant Creutzfeldt-Jakob disease with the pulvinar sign: MR imaging findings
in 86 neuropathologically confirmed cases.
AJNR Am J Neuroradiol.
2003;
24
1560-1569
- 42
Kallenberg K, Schulz-Schaeffer W J, Jastrow U. et al .
Creutzfeldt-Jakob disease: comparative analysis of MR imaging sequences.
AJNR Am J Neuroradiol.
2006;
27
1459-1462
- 43
Ukisu R, Kushihashi T, Kitanosono T. et al .
Serial diffusion-weighted MRI of Creutzfeldt-Jakob disease.
AJR Am J Roentgenol.
2005;
184
560-566
- 44
Mittal S, Farmer P, Kalina P. et al .
Correlation of diffusion-weighted magnetic resonance imaging with neuropathology in
Creutzfeldt-Jakob disease.
Arch Neurol.
2002;
59
128-134
- 45
Haik S, Dormont D, Faucheux B A. et al .
Prion protein deposits match magnetic resonance imaging signal abnormalities in Creutzfeldt-Jakob
disease.
Ann Neurol.
2002;
51
797-799
- 46
White M L, Zhang Y, Andrew L G. et al .
MR imaging with diffusion-weighted imaging in acute and chronic Wernicke encephalopathy.
AJNR Am J Neuroradiol.
2005;
26
2306-2310
- 47
Chu K, Kang D W, Kim H J. et al .
Diffusion-weighted imaging abnormalities in Wernicke encephalopathy: reversible cytotoxic
edema?.
Arch Neurol.
2002;
59
123-127
- 48
Koci T M, Chiang F, Chow P. et al .
Thalamic extrapontine lesions in central pontine myelinolysis.
AJNR Am J Neuroradiol.
1990;
11
1229-1233
- 49
Cramer S C, Stegbauer K C, Schneider A. et al .
Decreased diffusion in central pontine myelinolysis.
AJNR Am J Neuroradiol.
2001;
22
1476-1479
Dr. Jennifer Linn
Abteilung für Neuroradiologie Universitätsklinikum München
Marchioninistrasse 15
81377 München
Phone: ++49/89/70 95 32 61
Fax: ++49/89/70 95 25 09
Email: linn@nrad.de