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Horm Metab Res 2007; 39(11): 806-812
DOI: 10.1055/s-2007-991167
Original Basic

© Georg Thieme Verlag KG Stuttgart · New York

Diverse FSH and Testosterone Signaling Pathways in the Sertoli Cell

E. S. Loss 1 , A. P. Jacobus 1 , 2 , G. F. Wassermann 1
  • 1Departamento de Fisiologia, ICBS, UFRGS, Porto Alegre, RS, Brazil
  • 2Centro Universitário Metodista IPA, Porto Alegre, RS, Brazil
Further Information

Publication History

received 03.01.2007

accepted 24.04.2007

Publication Date:
09 November 2007 (online)

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Abstract

FSH and testosterone exert different regulatory effects on the seminiferous epithelium; they act through multiple and complex signaling routes to direct the development of the germ cells into mature spermatozoa. In addition to their well-known pathways of action, both hormones have recently been recognized to have new signaling routes that are linked to the Ca2+ ion, including, among others, the regulation of cell proliferation by FSH and the regulation of cell migration by testosterone.

Key words

FSH - testosterone - Sertoli cell - Ca2+ - rapid signaling

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Correspondence

G. F. Wassermann

Departamento de Fisiologia

ICBS

UFRGS

Rua Sarmento Leite 500

Porto Alegre

Rio Grande do Sul

90050-120 CEP

Brazil

Phone: +55/51/3308 33 02

Fax: +55/51/3308 33 02

Email: gwass@ufrgs.br

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