Diverse FSH and Testosterone Signaling Pathways in the Sertoli Cell

Abstract

FSH and testosterone exert different regulatory effects on the seminiferous epithelium; they act through multiple and complex signaling routes to direct the development of the germ cells into mature spermatozoa. In addition to their well-known pathways of action, both hormones have recently been recognized to have new signaling routes that are linked to the Ca²⁺ ion, including, among others, the regulation of cell proliferation by FSH and the regulation of cell migration by testosterone.

Key words

FSH - testosterone - Sertoli cell - Ca²⁺ - rapid signaling

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