Abstract
A new rearranged nor-secoiridoid, anthocleistenolide (1), along with the known 1-hydroxy-3,7-dimethoxyxanthone (2), 1-hydroxy-3,7,8-trimethoxyxanthone (3), 7α-hydroxysitosterol (4) and sitosterol 3-O-β-D-glucopyranoside (5), were isolated from the stem bark of Anthocleista vogelii. Their structures were elucidated on the basis of spectral studies and comparison
with published data. Compounds 1 - 3 and 5 were evaluated for their antibacterial and antifungal activities. Relatively low
anti-staphylococcal (MIC = 200 μg/mL against Staphylococcus aureus) and anti-enterococcal (MIC = 100 μg/mL against Enterococcus faecalis) activities were observed for 1, while compounds 2 and 3 were active against Candida parapsilosis (MIC = 200 μg/mL for 2 and 25 μg/mL for 3). Compound 5 was inactive against all the bacterial and fungal species used.
Key words
Anthocleista vogelii
- Gentianaceae - nor-secoiridoid - anthocleistenolide - xanthones - antimycrobial
activity
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Dr. Mathieu Tene
Department of Chemistry
University of Dschang
P. O. Box 67
Dschang
Cameroon
Phone: +237-7780-8420
Fax: +237-3345-1735
Email: mtene2001@yahoo.fr
