Ultraschall Med 2009; 30(6): 558-563
DOI: 10.1055/s-2008-1027948
Originalarbeit/Original Article

© Georg Thieme Verlag KG Stuttgart · New York

Long-Term Outcome for Children Born After a First-Trimester Measurement of Increased Nuchal Translucency with a Normal Karyotype: A Retrospective Analysis

Langzeitoutcome von Feten mit erweiterter Nackentransparenz und normalem Karyotyp: retrospektive AnalyseR. Axt-Fliedner1 , D. Hartge2 , A. Chiriac2 , M. Krapp3 , C. Berg4 , A. Geipel4 , U. Germer5 , U. Gembruch4
  • 1OB&GYN, University Gießen and Marburg, Division of Prenatal Medicine
  • 2OB&GYN, University of Schleswig-Holstein, Campus Luebeck, Division of Prenatal Medicine
  • 3Endokrinologikum Hamburg, Division of Prenatal Medicine
  • 4Universitäts-Frauenklinik Bonn, Division of Prenatal Medicine
  • 5Caritas St.-Josefs-Krankenhaus, Division of Prenatal Medicine
Further Information

Publication History

received: 15.5.2008

accepted: 27.10.2008

Publication Date:
09 January 2009 (online)

Zusammenfassung

Ziel: Beschreibung des Langzeitoutcomes von Feten mit erhöhter Nackentransparenz und normalem Karyotyp im Hinblick auf intrauterine Fruchttode, strukturelle Anomalien, Syndrome und neurologisches Handicap. Material und Methoden: Retrospektive Analyse und Telefoninterview. Alle eingeschlossenen Schwangerschaften mussten eine detaillierte Fehlbildungssonografie im 2. Trimenon aufweisen. Ergebnisse: 279 Schwangerschaften wurden untersucht. Die Over-all-Lebendgeburtenrate war 81,4 %, mit zunehmender NT-Dicke war die Zahl der Lebendgeburten deutlich rückläufig. Herzfehler waren die häufigsten strukturellen Anomalien (7 %). Bei unauffälligem Fehlbildungsultraschall wurde in 92 % ein gesundes Kind geboren. Unerwartete neurologische Beeinträchtigungen traten in 1,1 % der Fälle auf. Schlussfolgerung: In der Beratung der werdenden Eltern in Fällen mit euploiden Feten, erweiterter Nackentransparenz und unauffälligem Fehlbildungsultraschall im 2. Trimenon sollte die günstige Prognose für diese Schwangerschaften betont werden.

Abstract

Purpose: To study the outcome of pregnancy in chromosomally normal fetuses with increased nuchal translucency with respect to fetal loss, structural defects genetic syndromes, and neurological outcome. Materials and Methods: Retrospective analysis and telephone interview. All included pregnancies underwent a mid-trimester anomaly scan. Results: 279 pregnancies were included. The overall live birth rate was 81.4 %, and decreased as the NT measurement increased. The most common structural defect was cardiac anomalies (7 %). If the second-trimester anomaly scan was uneventful, the chance of a healthy live birth was 92 %. The number of unexpected neurodevelopmental delays after a normal scan during mid-trimester was 1.1 %. Conclusion: Counseling should emphasize that if the karyotype is normal and no fetal structural malformations were missed prenatally after resolution of nuchal thickening, the prognosis is positive.

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Prof. Roland Axt-Fliedner

OB&GYN, University Gießen and Marburg, Division of Prenatal Medicine

Klinikstraße 28

35385 Gießen

Phone: ++ 49/6 41/9 94 51 00

Fax: ++ 49/6 41/9 94 51 09

Email: raxtfliedner@hotmail.com