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DOI: 10.1055/s-2008-1062716
© Georg Thieme Verlag KG Stuttgart · New York
Relation of Spasms and Myoclonus to Suppression-Burst on EEG in Epileptic Encephalopathy in Early Infancy
Publication History
received 06.09.2007
accepted after revision 15.02.2008
Publication Date:
10 March 2008 (online)
Abstract
Purpose: This study was intended to clarify the relation between spasms in series and a suppression-burst (SB) EEG pattern which have a common nature of repetitive bursting activity in epileptic encephalopathy in early infancy.
Methods: The ictal EEG traces of spasms were temporally compressed and expanded to study the beginning and ending phases of series along with their spectral analysis in two patients with Ohtahara syndrome (OS) and one with early myoclonic encephalopathy (EME). The EEG bursts associated with myoclonus were also investigated.
Results: A mutual transition was indicated between the ictal activity of spasms and the bursts in the peri-series SB on EEG. Gamma rhythm was detected in common in the ictal activity and the peri-series and interictal bursts on EEG, and also in the bursts with myoclonus.
Conclusion: The relation between the ictal activity of spasms and SB on EEG was shown to be close. The generative mechanisms of spasms and myoclonus might be linked to the bursting tendency intrinsic to immature brain function.
Key words
spasms - epileptic encephalopathy - EEG analysis - myoclonus
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Correspondence
MD K. Kobayashi
Department of Child Neurology
Okayama University Hospital
Shikatacho 2-chome 5-1
Okayama 700-8558
Japan
Phone: +81/86/235 73 72
Fax: +81/86/235 73 77
Email: k_koba@md.okayama-u.ac.jp