Abstract
The multicomponent condensation of various β-dicarbonyl compounds, acrolein and (S )-2-phenylglycinol was found to provide a one-pot access to chiral 6-carbonyl-3-phenyl-2,3,8,8a-tetrahydro-7H -[1,3]oxazolo[3,2-a ]pyridines. The value of this methodology is illustrated by the short and efficient
synthesis of (-)-lupinine.
Key words
multicomponent reaction - tetrahydropyridines - oxazolidine - asymmetric synthesis
- alkaloids
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