Zusammenfassung
Veränderungen im Knochenstoffwechsel in der Onkologie sind nicht nur von Bedeutung
durch die Bildung von Knochenmetastasen als Folge von Primärerkrankungen wie Mammakarzinom
oder Prostatakrebs, sondern treten in jüngster Zeit auch in den Blickpunkt aufgrund
der adjuvanten Therapie des Mammakarzinoms, besonders mit den Aromatasehemmern, die
zu einer ausgeprägten Östrogendeprivation führen. Ziel dieser Übersichtsarbeit ist
es, neben dem aktuellen Stand der Forschung auch Überblicke über Diagnose und Behandlungsstrategie
hinsichtlich Veränderungen des Knochenstoffwechsels im Bereich der Onkologie zu geben.
Abstract
Changes in bone metabolism in oncological patients have a clinical significance for
the formation of bone metastasis during the course of primary diseases such as breast
cancer or prostate cancer. In addition, attention is currently being focused on bone
metabolism changes during adjuvant therapies for breast cancer, especially after the
administration of aromatase inhibitors which lead to estrogen deprivation. The aim
of the present review is to give an overview of the current scientific state of the
art together with a summary on the diagnosis and treatment strategies with respect
to changes of bone metabolism in oncology.
Schlüsselwörter
Knochenstoffwechsel - Onkologie - Diagnose - Therapie
Key words
bone metabolism - oncology - diagnosis - therapy
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Prof. Dr. H. Seeger
Schwerpunkt für Endokrinologie und Menopause Universitäts-Frauenklinik
Calwer Straße 7
72076 Tübingen
eMail: endo.meno@med.uni-tuebingen.de