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Senologie - Zeitschrift für Mammadiagnostik und -therapie 2008; 5(3): 162-167
DOI: 10.1055/s-2008-1076813
Wissenschaftliche Arbeit

© Georg Thieme Verlag KG Stuttgart ˙ New York

Knochenstoffwechsel in der Onkologie

Tumor- und therapieinduzierte Veränderungen im KnochenstoffwechselBone Metabolism in OncologyTumor- and Therapy-Induced Changes in Bone MetabolismH. Seeger1 , T. Fehm1 , B. Krämer1 , E. Solomayer1 , P. Hadji2
  • 1Universitäts-Frauenklinik Tübingen
  • 2Universitäts-Frauenklinik Marburg
Further Information

Publication History

2007

2008

Publication Date:
30 September 2008 (online)

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Zusammenfassung

Veränderungen im Knochenstoffwechsel in der Onkologie sind nicht nur von Bedeutung durch die Bildung von Knochenmetastasen als Folge von Primärerkrankungen wie Mammakarzinom oder Prostatakrebs, sondern treten in jüngster Zeit auch in den Blickpunkt aufgrund der adjuvanten Therapie des Mammakarzinoms, besonders mit den Aromatasehemmern, die zu einer ausgeprägten Östrogendeprivation führen. Ziel dieser Übersichtsarbeit ist es, neben dem aktuellen Stand der Forschung auch Überblicke über Diagnose und Behandlungsstrategie hinsichtlich Veränderungen des Knochenstoffwechsels im Bereich der Onkologie zu geben.

Abstract

Changes in bone metabolism in oncological patients have a clinical significance for the formation of bone metastasis during the course of primary diseases such as breast cancer or prostate cancer. In addition, attention is currently being focused on bone metabolism changes during adjuvant therapies for breast cancer, especially after the administration of aromatase inhibitors which lead to estrogen deprivation. The aim of the present review is to give an overview of the current scientific state of the art together with a summary on the diagnosis and treatment strategies with respect to changes of bone metabolism in oncology.

Schlüsselwörter

Knochenstoffwechsel - Onkologie - Diagnose - Therapie

Key words

bone metabolism - oncology - diagnosis - therapy

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Prof. Dr. H. Seeger

Schwerpunkt für Endokrinologie und Menopause
Universitäts-Frauenklinik

Calwer Straße 7

72076 Tübingen

Email: endo.meno@med.uni-tuebingen.de