Kardiologie 2008

Was ist neu?

• Myokardinfarkt mit ST-Streckenhebung (STEMI): Thrombozytenaggregationshemmung im Umbruch

• Aortenstenose: Perkutane Klappenimplantation gewinnt klinische Bedeutung

• Arterielle Hypertonie: Frühe Kombination aus ACE-Hemmer und Calciumantagonist günstig

• Risikofaktor Hypercholesterinämie: Statine bleiben Therapie der Wahl

• Chronische Herzinsuffizienz: Kein weiterer therapeutischer Durchbruch

• Kardiovaskulärer Risikopatient: AT₁-Antagonist genauso wirksam wie ACE-Hemmer

Literatur

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• 2 Barter P J, Caulfield M, Eriksson M. et al . Effects of torcetrapib in patients at high risk for coronary events.  N Engl J Med. 2007;  357 2109-22
• 3 Beshai J F, Grimm R A, Nagueh S F. et al . Cardiac-resynchronization therapy in heart failure with narrow QRS complexes.  N Engl J Med. 2007;  357 2461-71
• 4 Grube E, Schuler G, Buellesfeld L. et al . Percutaneous aortic valve replacement for severe aortic stenosis in high-risk patients using the second- and current third-generation self-expanding CoreValve prosthesis: device success and 30-day clinical outcome.  J Am Coll Cardiol. 2007;  50 69-76
• 5 Jamerson K A. Avoiding Cardiovascular Events Through COMbination Therapy in Patients LIving with Systolic Hypertension, the Early Termination of the ACCOMPLISH Trial for Efficacy. Abstract. ACC 2008
• 6 Kastelein J J, Akdim F, Stroes E S. et al . Simvastatin with or without ezetimibe in familial hypercholesterolemia.  N Engl J Med. 2008;  358 1431-43
• 7 Kjekshus J, Apetrei E, Barrios V. et al . Rosuvastatin in older patients with systolic heart failure.  N Engl J Med. 2007;  357 2248-61
• 8 Mehilli J. Pretreatment With a High Loading Dose of Clopidogrel and Value of Abciximab During Primary Coronary Intervention in Patients With Acute Myocardial Infarction. Results of the Randomized BRAVE-3 Trial. Abstract. ACC 2008
• 9 Webb J G, Pasupati S, Humphries K. et al . Percutaneous transarterial aortic valve replacement in selected high-risk patients with aortic stenosis.  Circulation. 2007;  116 755-63
• 10 Yusuf S, Teo K K, Pogue J. et al . Telmisartan, ramipril, or both in patients at high risk for vascular events.  N Engl J Med. 2008;  358 1547-59