Type II transmembrane serine proteases

Roman Szabo; Qingyu Wu; Robert B. Dickson; Sarah Netzel-Arnett; Toni M. Antalis; Thomas H. Bugge

doi:10.1160/TH03-02-0071

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2003; 90(02): 185-193
DOI: 10.1160/TH03-02-0071

Review Article

Schattauer GmbH

Type II transmembrane serine proteases

Roman Szabo

¹Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA

,

Qingyu Wu

²Berlex Biosciences, Richmond, California, USA

,

Robert B. Dickson

³Lombardi Cancer Center, Georgetown University Medical Center, Washington, District of Colombia, USA

,

Sarah Netzel-Arnett

⁴Vascular Biology Department, Jerome H. Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland, USA

,

Toni M. Antalis

⁴Vascular Biology Department, Jerome H. Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland, USA

,

Thomas H. Bugge

¹Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA

› Author Affiliations

Abstract

Summary

The recent availability of human and mouse genome sequences and expressed sequence tag databases facilitated the identification of a large new family of membrane anchored serine proteases, the type II transmembrane serine proteases or TTSPs. Analyses of human inherited disorders and gene targeting studies in mice have revealed that several members of this new protease family have critical functions in development and health. Preliminary studies also suggest that aberrant expression of type II transmembrane serine proteases may be linked to disease progression. The knowledge gathered thus far of the genetics, physiology, and pathology of this interesting new serine protease family will be reviewed here in brief.

Keywords

Serine proteases - cell surface proteolysis - transmembrane

Full Text

References

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