Neutrophil function in the healing wound: adding insult to injury?

Julia V. Dovi; Anna M. Szpaderska; Luisa A. DiPietro

doi:10.1160/TH03-11-0720

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 92(02): 275-280
DOI: 10.1160/TH03-11-0720

Theme Issue Article

Schattauer GmbH

Neutrophil function in the healing wound: adding insult to injury?

Authors

Julia V. Dovi

¹Burn and Shock Trauma Institute, Department of Surgery, Loyola University Medical Center Maywood, Illinois, USA
Anna M. Szpaderska

¹Burn and Shock Trauma Institute, Department of Surgery, Loyola University Medical Center Maywood, Illinois, USA
Luisa A. DiPietro

¹Burn and Shock Trauma Institute, Department of Surgery, Loyola University Medical Center Maywood, Illinois, USA

Abstract

Summary

Cells of the innate immune system, including neutrophils and macrophages, are a highly visible component of normal wound healing in adult mammals. The role of inflammatory cells in the healing wound has been widely investigated, and evidence for both positive and negative influences exists. Several recent investigations support the emerging paradigm that robust inflammation is detrimental to wound closure. This developing information suggests that the functional role of inflammatory cells in wound healing must be reevaluated.

Keywords

Wound healing - neutrophils - macrophages - inflammation

Full Text

References

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