Prevention of central venous line-related thrombosis by continuous infusion of low-dose unfractionated heparin, in patients with haemato-oncological disease

Abderrahman Abdelkefi; Tarek Ben Othman; Leïla Kammoun; Mouna Chelli; Neïla Ben Romdhane; Azza Kriaa; Saloua Ladeb; Lamia Torjman; Amel Lakhal; Wafa Achour; Assia Ben Hassen; Mohamed Hsaïri; Fethi Ladeb; Abdeladhim Ben Abdeladhim

doi:10.1160/TH04-02-0087

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 92(03): 654-661
DOI: 10.1160/TH04-02-0087

Cellular Proteolysis and Oncology

Schattauer GmbH

Prevention of central venous line-related thrombosis by continuous infusion of low-dose unfractionated heparin, in patients with haemato-oncological disease

A randomized controlled trial

Authors

Abderrahman Abdelkefi

¹Centre National de Greffe de Moelle Osseuse,Tunis,Tunisia
Tarek Ben Othman

¹Centre National de Greffe de Moelle Osseuse,Tunis,Tunisia
Leïla Kammoun

¹Centre National de Greffe de Moelle Osseuse,Tunis,Tunisia
Mouna Chelli

²Institut Kassab,Tunis,Tunisia
Neïla Ben Romdhane

³Hôpital de La Rabta,Tunis,Tunisia
Azza Kriaa

³Hôpital de La Rabta,Tunis,Tunisia
Saloua Ladeb

¹Centre National de Greffe de Moelle Osseuse,Tunis,Tunisia
Lamia Torjman

¹Centre National de Greffe de Moelle Osseuse,Tunis,Tunisia
Amel Lakhal

¹Centre National de Greffe de Moelle Osseuse,Tunis,Tunisia
Wafa Achour

¹Centre National de Greffe de Moelle Osseuse,Tunis,Tunisia
Assia Ben Hassen

¹Centre National de Greffe de Moelle Osseuse,Tunis,Tunisia
Mohamed Hsaïri

⁴Institut National de la Santé Publique,Tunis,Tunisia
Fethi Ladeb

²Institut Kassab,Tunis,Tunisia
Abdeladhim Ben Abdeladhim

¹Centre National de Greffe de Moelle Osseuse,Tunis,Tunisia

Abstract

Summary

We have conducted a prospective randomized controlled trial to evaluate the role of low-dose unfractionated heparin prophylaxis in preventing central venous line-related thrombosis in patients with haemato-oncological disease. Patients were randomly assigned to receive either prophylactic intravenous unfractionated heparin (continuous infusion of 100 IU/kg/daily) or 50 ml/daily of normal saline solution as a continuous infusion. CVLs were externalized, non tunneled, double lumen catheters. All CVLs were placed percutaneously by the same physician in the subclavian vein. Upper limb veins were systematically examined by ultrasonography just before, or < 24 hours after, catheter removal, and in case of clinical signs of thrombosis. One hundred and twenty-eight CVLs were inserted. Catheterrelated thrombosis occurred in 1.5% of the catheters inserted in patients of the heparin group, and in 12.6% in the control group (p = 0.03). No other risk factors were found for the development of catheter-related thrombosis. Two and three patients experienced severe bleeding in the heparin group, and in the control group, respectively (p = 0.18). There were no other side-effects clearly ascribable to the use of unfractionated heparin. This is the first prospective, randomized study, which shows that low-dose of unfractionated heparin is safe and effective to prevent catheter-related thrombosis in patients with haemato-oncological disease.

Keywords

Central venous catheter - thrombosis - heparin

Full Text

References

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