Medical conditions increasing the risk of chronic thromboembolic pulmonary hypertension

Diana Bonderman; Johannes Jakowitsch; Christopher Adlbrecht; Michael Schemper; Paul A. Kyrle; Verena Schönauer; Markus Exner; Walter Klepetko; Meinhard P. Kneussl; Gerald Maurer; Irene Lang

doi:10.1160/TH04-10-0657

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2005; 93(03): 512-516
DOI: 10.1160/TH04-10-0657

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Medical conditions increasing the risk of chronic thromboembolic pulmonary hypertension

Authors

Diana Bonderman

¹Medical University of Vienna, Departments of Cardiology, Medical University of Vienna, Vienna, Austria
Johannes Jakowitsch

¹Medical University of Vienna, Departments of Cardiology, Medical University of Vienna, Vienna, Austria
Christopher Adlbrecht

¹Medical University of Vienna, Departments of Cardiology, Medical University of Vienna, Vienna, Austria
Michael Schemper

²Department of Medical Computer Sciences; Medical University of Vienna, Vienna, Austria
Paul A. Kyrle

³Department of Hematology; Medical University of Vienna, Vienna, Austria
Verena Schönauer

³Department of Hematology; Medical University of Vienna, Vienna, Austria
Markus Exner

⁴Department of Laboratory Medicine; Medical University of Vienna, Vienna, Austria
Walter Klepetko

⁵Department of Cardiothoracic Surgery; Medical University of Vienna, Vienna, Austria
Meinhard P. Kneussl

⁶Department of Pulmonary Medicine; Medical University of Vienna, Vienna, Austria
Gerald Maurer

¹Medical University of Vienna, Departments of Cardiology, Medical University of Vienna, Vienna, Austria
Irene Lang

¹Medical University of Vienna, Departments of Cardiology, Medical University of Vienna, Vienna, Austria

Abstract

Summary

Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by organized thromboemboli that obstruct the pulmonary vascular bed. Although CTEPH is a serious complication of acute symptomatic pulmonary embolism in 4% of cases, signs, symptoms and classical risk factors for venous thromboembolism are lacking. The aim of the present study was to identify medical conditions conferring an increased risk of CTEPH. We performed a case-control-study comparing 109 consecutive CTEPH patients to 187 patients with acute pulmonary embolism that was confirmed by a high probability lung scan. Splenectomy (odds ratio=13, 95% CI 2.7–127), ventriculoatrial (VA-) shunt for the treatment of hydrocephalus (odds ratio=13, 95% CI 2.5–129) and chronic inflammatory disorders, such as osteomyelitis and inflammatory bowel disease (IBD, odds ratio=67, 95% CI 7.9–8832) were associated with an increased risk of CTEPH.

Keywords

Pulmonary embolism - clinical / epidemiological studies - acquired coagulation disorders - infection / bacterial - viral

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Referenzen

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