Chlamydophila pneumoniae

Matthias Krüll; Matthias Maass; Norbert Suttorp; Jan Rupp

doi:10.1160/TH05-04-0261

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2005; 94(02): 319-326
DOI: 10.1160/TH05-04-0261

Theme Issue Article

Schattauer GmbH

Chlamydophila pneumoniae

Mechanisms of target cell infection and activation

Authors

Matthias Krüll

¹Department. of Internal Medicine/Infectious Diseases, Charité, Universitätsmedizin Berlin, Berlin, Germany
Matthias Maass

²SALK Labor, Salzburger Landeskliniken, Salzburg, Austria
Norbert Suttorp

¹Department. of Internal Medicine/Infectious Diseases, Charité, Universitätsmedizin Berlin, Berlin, Germany
Jan Rupp

³Institute of Medical Microbiology and Hygiene, University of Lübeck, Lübeck, Germany

Abstract

Summary

Chlamydophila (Chlamydia) pneumoniae, a gram-negative obligate intracellular bacterium, is a widespread respiratory pathogen. Chronic C. pneumoniae infection has been suggested as a trigger/ promoter of inflammation that may result in vascular lesions. Although the genome of C. pneumoniae has been sequenced completely this information has not yet led to an understanding of the mechanisms of acute infection and target cell activation nor to the identification of potential chlamydial virulence factors. Intriguingly, current antibiotic treatment options for acute chlamy- dial infection were proven to be ineffective with respect to clinical outcome in different groups of atherosclerotic patients. The reason might be that primary infection of vascular smooth muscle cells and blood monocytes with C. pneumoniae resembles rather a persistent, antibiotic-resistant, than an active infection. In this review we will focus on the importance of putative host cell receptors for C.pneumoniae and subsequently activated signal transduction pathways.

Keywords

Atherosclerosis - endothelial cells - infection / bacterial - viral - signal transduction - bacteria

Full Text

References

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