lnterleukin-6 is a determinant of PAI-1 levels in diabetic subjects with the 4G allele at position -675 of the PAI-1 gene

Anna Rita Bonfigli; Maurizio Marra; Cristina Sirolla; Massimo Boemi; Daniela Mari; Elisabetta Sacchi; Antonio Procopio; Rina Recchioni; Claudio Franceschi; Simona Giovagnetti; Roberto Testa

doi:10.1160/TH05-07-0490

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2006; 95(03): 587-588
DOI: 10.1160/TH05-07-0490

Letters to the Editor

Schattauer GmbH

lnterleukin-6 is a determinant of PAI-1 levels in diabetic subjects with the 4G allele at position -675 of the PAI-1 gene

Authors

Anna Rita Bonfigli

¹Diabetology Unit, INRCA, Ancona
Maurizio Marra

¹Diabetology Unit, INRCA, Ancona
Cristina Sirolla

¹Diabetology Unit, INRCA, Ancona
Massimo Boemi

¹Diabetology Unit, INRCA, Ancona
Daniela Mari

²IRCCS Maggiore Hospital, Department of Internal Medicine, Milan
Elisabetta Sacchi

³L. Sacco Hospital, Department of Immunology and Transfusion, Milan
Antonio Procopio

⁴Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona

⁵Centre of Otology, INRCA, Ancona
Rina Recchioni

⁵Centre of Otology, INRCA, Ancona
Claudio Franceschi

⁶Centre of Molecular Biology and Genetics, INRCA, Ancona

⁷Department of Experimental Pathology, University of Bologna; Italy
Simona Giovagnetti

⁶Centre of Molecular Biology and Genetics, INRCA, Ancona
Roberto Testa

¹Diabetology Unit, INRCA, Ancona

Abstract

Full Text

References

References
1 Juhan-vague I, Alessi MC, Mavri A. et al. Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk. J Thromb Haemost 2003; 01: 1575-9.
2 Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 2004; 27: 813-23.
3 Dong J, Fujii S, Li H. et al. Interleukin-6 and mev-astatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-delta. Arte-rioscler Thromb Vase Biol 2005; 25: 1078-84.
4 Rega G, Kaun C, Weiss TW. et al. Inflammatory cytokines interleukin-6 and oncostatin m induce plasminogen activator inhibitor-1 in human adipose tissue. Circulation 2005; 111: 1938-15.
5 Dawson SJ, Wiman B, Hamsten A. et al. The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells. J Biol Chem 1993; 268: 10739-15.
6 Plomgaard P, Keller P, Keller C. et al. TNF-a but not IL-6, stimulates plasminogen activator inhibitor 1 (PAI-1) expression inhuman subcutaneous adipose tissue. J Appl Physiol 2005; 98: 2019-23.
7 Bastelica D, Mavri A, Verdierl M. et al. Relationships between fibrinolytic and inflammatory parameters inhuman adipose tissue: strong contribution of TNF-a receptors to PAI-1 levels. Thromb Haemost 2002; 88: 481-7.
8 Panahloo A, Mohamed-Ali V, Gray RP. et al. Plasminogen activator inhibitor-1 (PAI-1) activity post myocardial infarction: the role of acute phase reactants, insulin-like molecules and promoter (4G/5G) polymorphism in the PAI-1 gene. Atherosclerosis 2005; 168: 297-304.
9 Hoekstra T, Geleijnse JM, Schouten EG. et al. Plasminogen activator inhibitor-type I: its plasma determinants and relation with cardiovascular risk. Thromb Haemost 2004; 91: 861-72.