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Thromb Haemost 2007; 98(01): 20-23
DOI: 10.1160/TH07-04-0284
DOI: 10.1160/TH07-04-0284
Anniversary Issue Contribution
The initiation phase – A review of old (clotting-) times
Further Information
Correspondence to:
Prof. H. C. Hemker
Synapse BV, University Maaastricht/CARIM
PO Box 616, Maastricht, Limburg
6200 MD, The Netherlands
Phone: +31 43388 1675
Fax: +31 43388 4159
Email: hc.hemker@thrombin.com
Publication History
Received
17 April 2007
Accepted
09 May 2007
Publication Date:
29 November 2017 (online)
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References
- 1 Stormorken H, Paul A. Owren & the golden era of haemostasis. Sandvika: Gazettebok; 2005
- 2 Loeliger van der Eb EA, Mattern MJ. et al. Behaviour of factors II, VII, IX and X during long-term treatment with coumarin. Thromb Diath Haemorrh 1963; 9: 74-89.
- 3 Hemker HC, Veltkamp JJ, Hensen A. et al. Nature Of Prothrombin Biosynthesis: Preprothrombinaemia In Vitamin K-Deficiency. Nature 1963; 200: 589-590.
- 4 Hemker HC, Muller AD, Loeliger EA. Two types of prothrombin in vitamin K deficiency. Thromb Diath Haemorrh 1970; 23: 633-637.
- 5 Ganrot PO, Nilehn JE. Plasma prothrombin during treatment with Dicumarol. II. Demonstration of an abnormal prothrombin fraction. Scand J Clin Lab Invest 1968; 22: 23-28.
- 6 Stenflo J. From gamma-carboxy-glutamate to protein C. J Thromb Haemost 2006; 4: 2521-2526.
- 7 Josso F, Lavergne JM, Gouault M. et al. Various molecular states of factor II (prothrombin). Their study by means of staphylocoagulase and anti-factor II antibodies. I. Factor II in patients treated with vitamin K antagonists. Thromb Diath Haemorrh 1968; 20: 88-98.
- 8 Hemker HC, Hemker PW, Loeliger EA. Kinetic aspects of the interaction of blood-clotting enzymes. I. Derivation of basic formulas. Thromb Diath Haemorrh 1967; 13: 155-175.
- 9 Hemker HC, Siepel T, Altman R. et al. Kinetic aspects of the interaction of blood-clotting enzymes. II. The relation between clotting time and plasma concentration in prothrombin- time estimations. Thromb Diath Haemorrh 1967; 17: 349-357.
- 10 Hemker HC, Veltkamp JJ, Loeliger EA. Kinetic aspects of the interaction of blood clotting enzymes. III. Demonstration of an inhibitor of prothrombin conversion in vitamin K deficiency. Thromb Diath Haemorrh 1968; 19: 346-363.
- 11 Hemker HC, Hemker PW. Kinetic aspects of the interaction of blood clotting enzymes. IV. Kinetics of competitive inhibition in clotting tests. Thromb Diath Haemorrh 1968; 19: 364-367.
- 12 Hemker HC, Muller AD. Kinetic aspects of the interaction of blood clotting enzymes. V. The reaction mechanism of the extrinsic clotting system as revealed by the kinetics of one-stage estimations of coagulation enzymes. Thromb Diath Haemorrh 1968; 19: 368-382.
- 13 Hemker HC, Muller AD. Kinetic aspects of the interaction of blood-clotting enzymes. VI. Localization of the site of blood-coagulation inhibition by the protein induced by vitamin K absence (PIVKA). Thromb Diath Haemorrh 1968; 20: 78-87.
- 14 Hemker HC, Vermeer C, Govers-Riemslag J. Kinetic aspects of the interaction of blood clotting enzymes. VII. The relation between clotting time and prothrombin concentration. Thromb Haemost 1977; 37: 81-85.
- 15 Hemker HC, Kop J, Willems GM. Kinetic aspects of the interaction of blood clotting enzymes. VIII. The relation between clotting time and clotting velocity. Thromb Haemost 1979; 41: 309-313.
- 16 Hemker HC, Meer Jvd, Loeliger EA. Kinetic basis of prothrombin estimation particularly with reference to the rectilinearity of the log-log reference curve. Thromb Diath Haemorrh 1965; 17 Suppl 247-252.
- 17 Seegers WH, Nieft M, Loomis EC. Note on the adsorption of thrombin on fibrin. Science 1945; 101: 520-1.
- 18 Hemker HC, Al Dieri R, De Smedt E. et al. Thrombin generation, a function test of the haemostatic-thrombotic system. Thromb Haemost 2006; 96: 553-561.
- 19 Hemker HC, Esnouf MP, Hemker PW. et al. Formation of prothrombin converting activity. Nature 1967; 215: 248-251.
- 20 Hemker HC, Swart AC, Alink AJ. Artificial reagents for factor VII and factor X, a computer programme for obtaining reference tables for one-stage determinations in the extrinsic system. Thromb Diath Haemorrh 1972; 27: 205-211.
- 21 Hemker HC, Kahn MJ. Reaction sequence of blood coagulation. Nature 1967; 215: 1201-1202.
- 22 Hemker HC, Hemker PW, Torren Kvd. et al. The evaluation of the two-stage prothrombin assay. Thromb Diath Haemorrh 1971; 25: 545-554.
- 23 Varadi K, Hemker HC. Kinetics of the formation of the factor X activating enzyme of the blood coagulation system. Thromb Res 1976; 8: 303-317.
- 24 Rosing J, Tans G, Govers-Riemslag JW. et al. The role of phospholipids and factor Va in the prothrombinase complex. J Biol Chem 1980; 255: 274-283.
- 25 Van Dieijen G, Tans G, Rosing J, Hemker HC. The role of phospholipid and factor VIIIa in the activation of bovine factor X. J Biol Chem 1981; 256: 3433-3442.
- 26 de Metz M, Vermeer C, Soute BA. et al. Identification of phospholipid as an essential part of bovine vitamin K-dependent carboxylase. J Biol Chem 1981; 256: 10843-10846.
Correspondence to:
Prof. H. C. Hemker
Synapse BV, University Maaastricht/CARIM
PO Box 616, Maastricht, Limburg
6200 MD, The Netherlands
Phone: +31 43388 1675
Fax: +31 43388 4159
Email: hc.hemker@thrombin.com
-
References
- 1 Stormorken H, Paul A. Owren & the golden era of haemostasis. Sandvika: Gazettebok; 2005
- 2 Loeliger van der Eb EA, Mattern MJ. et al. Behaviour of factors II, VII, IX and X during long-term treatment with coumarin. Thromb Diath Haemorrh 1963; 9: 74-89.
- 3 Hemker HC, Veltkamp JJ, Hensen A. et al. Nature Of Prothrombin Biosynthesis: Preprothrombinaemia In Vitamin K-Deficiency. Nature 1963; 200: 589-590.
- 4 Hemker HC, Muller AD, Loeliger EA. Two types of prothrombin in vitamin K deficiency. Thromb Diath Haemorrh 1970; 23: 633-637.
- 5 Ganrot PO, Nilehn JE. Plasma prothrombin during treatment with Dicumarol. II. Demonstration of an abnormal prothrombin fraction. Scand J Clin Lab Invest 1968; 22: 23-28.
- 6 Stenflo J. From gamma-carboxy-glutamate to protein C. J Thromb Haemost 2006; 4: 2521-2526.
- 7 Josso F, Lavergne JM, Gouault M. et al. Various molecular states of factor II (prothrombin). Their study by means of staphylocoagulase and anti-factor II antibodies. I. Factor II in patients treated with vitamin K antagonists. Thromb Diath Haemorrh 1968; 20: 88-98.
- 8 Hemker HC, Hemker PW, Loeliger EA. Kinetic aspects of the interaction of blood-clotting enzymes. I. Derivation of basic formulas. Thromb Diath Haemorrh 1967; 13: 155-175.
- 9 Hemker HC, Siepel T, Altman R. et al. Kinetic aspects of the interaction of blood-clotting enzymes. II. The relation between clotting time and plasma concentration in prothrombin- time estimations. Thromb Diath Haemorrh 1967; 17: 349-357.
- 10 Hemker HC, Veltkamp JJ, Loeliger EA. Kinetic aspects of the interaction of blood clotting enzymes. III. Demonstration of an inhibitor of prothrombin conversion in vitamin K deficiency. Thromb Diath Haemorrh 1968; 19: 346-363.
- 11 Hemker HC, Hemker PW. Kinetic aspects of the interaction of blood clotting enzymes. IV. Kinetics of competitive inhibition in clotting tests. Thromb Diath Haemorrh 1968; 19: 364-367.
- 12 Hemker HC, Muller AD. Kinetic aspects of the interaction of blood clotting enzymes. V. The reaction mechanism of the extrinsic clotting system as revealed by the kinetics of one-stage estimations of coagulation enzymes. Thromb Diath Haemorrh 1968; 19: 368-382.
- 13 Hemker HC, Muller AD. Kinetic aspects of the interaction of blood-clotting enzymes. VI. Localization of the site of blood-coagulation inhibition by the protein induced by vitamin K absence (PIVKA). Thromb Diath Haemorrh 1968; 20: 78-87.
- 14 Hemker HC, Vermeer C, Govers-Riemslag J. Kinetic aspects of the interaction of blood clotting enzymes. VII. The relation between clotting time and prothrombin concentration. Thromb Haemost 1977; 37: 81-85.
- 15 Hemker HC, Kop J, Willems GM. Kinetic aspects of the interaction of blood clotting enzymes. VIII. The relation between clotting time and clotting velocity. Thromb Haemost 1979; 41: 309-313.
- 16 Hemker HC, Meer Jvd, Loeliger EA. Kinetic basis of prothrombin estimation particularly with reference to the rectilinearity of the log-log reference curve. Thromb Diath Haemorrh 1965; 17 Suppl 247-252.
- 17 Seegers WH, Nieft M, Loomis EC. Note on the adsorption of thrombin on fibrin. Science 1945; 101: 520-1.
- 18 Hemker HC, Al Dieri R, De Smedt E. et al. Thrombin generation, a function test of the haemostatic-thrombotic system. Thromb Haemost 2006; 96: 553-561.
- 19 Hemker HC, Esnouf MP, Hemker PW. et al. Formation of prothrombin converting activity. Nature 1967; 215: 248-251.
- 20 Hemker HC, Swart AC, Alink AJ. Artificial reagents for factor VII and factor X, a computer programme for obtaining reference tables for one-stage determinations in the extrinsic system. Thromb Diath Haemorrh 1972; 27: 205-211.
- 21 Hemker HC, Kahn MJ. Reaction sequence of blood coagulation. Nature 1967; 215: 1201-1202.
- 22 Hemker HC, Hemker PW, Torren Kvd. et al. The evaluation of the two-stage prothrombin assay. Thromb Diath Haemorrh 1971; 25: 545-554.
- 23 Varadi K, Hemker HC. Kinetics of the formation of the factor X activating enzyme of the blood coagulation system. Thromb Res 1976; 8: 303-317.
- 24 Rosing J, Tans G, Govers-Riemslag JW. et al. The role of phospholipids and factor Va in the prothrombinase complex. J Biol Chem 1980; 255: 274-283.
- 25 Van Dieijen G, Tans G, Rosing J, Hemker HC. The role of phospholipid and factor VIIIa in the activation of bovine factor X. J Biol Chem 1981; 256: 3433-3442.
- 26 de Metz M, Vermeer C, Soute BA. et al. Identification of phospholipid as an essential part of bovine vitamin K-dependent carboxylase. J Biol Chem 1981; 256: 10843-10846.